J Korean Ophthalmol Soc > Volume 58(2); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(2):178-184.
DOI: https://doi.org/10.3341/jkos.2017.58.2.178    Published online February 15, 2017.
The Association between Corneal Biomechanical Properties and Initial Visual Field Defect Pattern in Normal Tension Glaucoma.
Bo Ram Lee, Kyung Eun Han, Kyu Ryong Choi
The Institute of Ophthalmology and Optometry, Department of Ophthalmology, Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea. Ckrey@ewha.ac.kr
정상안압녹내장에서 초기 시야결손 유형과 각막생체역학인자의 관련성
이화여자대학교 의학전문대학원 목동병원 안과학교실 이화시과학 연구센터
Correspondence:  Kyu Ryong Choi,
Email: Ckrey @ewha.ac.kr
Received: 4 May 2016   • Revised: 15 June 2016   • Accepted: 8 August 2016
To investigate the association between corneal biomechanical properties and initial visual field defect pattern in normal tension glaucoma using an Ocular Response Analyzer (ORA; Reichert Instruments, Depew, NY, USA). METHODS: Forty-one patients with normal tension glaucoma were divided into 2 subgroups, 21 patients with initial paracentral scotomas and 20 patients with initial peripheral scotomas. The corneal biomechanical properties of corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), corneal-compensated IOP (IOPcc) measured by the ORA, central corneal thickness, and Goldmann applanation tonometry were comparatively analyzed between the 2 groups. RESULTS: The patients with initial peripheral scotomas were significantly younger than those with initial paracentral scotomas (49.45 ± 13.33 years vs. 58.14 ± 12.49 years, p = 0.035) and showed more myopia (− 2.42 ± 2.22 diopter vs. − 0.89 ± 2.22 diopter, p = 0.034). The mean CRF was significantly lower in the initial paracentral scotoma group than in the initial peripheral scotoma group. (9.45 ± 1.95 mmHg vs. 10.58 ± 2.05 mmHg; p = 0.041). No significant difference in CH, IOPg, or IOPcc was seen between the groups. CONCLUSIONS: CRF was significantly different between the initial paracentral scotoma group and initial peripheral scotoma group in normal tension glaucoma. Thus, CRF may be useful to predict initial central field loss in normal tension glaucoma.
Key Words: Initial paracentral scotoma;Initial peripheral scotoma;Normal tension glaucoma;Ocular response analysis

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