J Korean Ophthalmol Soc > Volume 57(1); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(1):134-140.
DOI: https://doi.org/10.3341/jkos.2016.57.1.134    Published online January 15, 2016.
Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis.
Young Ki Kwon, Dong Jin Kang, Jong Chan Lim, Jong Ho Kim, Dong Ho Park, Jae Pil Shin
Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea. Jps11@hanmail.net
결절성경화증에서 망막 성상세포과오종의 안저자가형광, 형광안저혈관조영 및 스펙트럼영역 빛간섭단층촬영 소견
권영기⋅강동진⋅임종찬⋅김종호⋅박동호⋅신재필
경북대학교 의학전문대학원 안과학교실
Abstract
PURPOSE
To analyze the structural and morphological characteristics of retinal astrocytic hamartomas in tuberous sclerosis patients using fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography. CASE SUMMARY: Fundus examination, fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography were performed in three patients with tuberous sclerosis and the morphological and structural characteristics of retinal astrocytic hamartomas were analyzed. In the fundus autofluorescence, type 1 retinal astrocytic hamartoma showed hypofluorescence and type 3 showed central hyperfluorescence and surrounding hypofluorescence. Spectral domain optical coherence tomography showed dome-shaped hyper-reflectivity within the nerve fiber layer and focal adhesion of the vitreous cortex in the type 1 retinal astrocytic hamartoma. No abnormalities were observed in the outer retinal layer and retinal pigment epithelium. In the type 3 retinal astrocytic hamartoma, optical coherence tomography showed disorganization of retinal tissue and posterior shadowing. Intratumoral cavitation and moth-eaten appearance caused by intratumoral calcification were observed and the vitreous cortex adhered to the top of the tumor and showed traction. Retinal arterial sheathing was observed in all cases and hyper- reflectivity of the arterial wall was noted on optical coherence tomography. CONCLUSIONS: Fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography are helpful for the classification and diagnosis of retinal astrocytic hamartomas found in tuberous sclerosis patients as well as for differentiation from other lesions.
Key Words: Fluorescein angiography;Fundus autofluorescence;Optical coherence tomography;Retinal astrocytic hamartoma;Tuberous sclerosis


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