| Two Cases of Corneal Toxicity in Acanthamoeba Keratitis by Combined Topical Anti-Acanthamoeba Keratitis Eye Solution. |
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Ja Kyun Lee, Jong Soo Lee |
1Department of Ophthalmology, Pusan National University School of Medicine, Busan, Korea. jongsool@pusan.ac.kr
2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. |
| 가시아메바각막염의 복합 치료약제에 의한 각막독성 2예 |
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이자균1⋅이종수1,2 |
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부산대학교 의학전문대학원 안과학교실1, 부산대학교병원 의생명연구원2 |
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| Abstract |
PURPOSE
To present a case of corneal toxicity caused by therapeutic duplication during treatment of acanthamoeba keratitis as a complication of contact lens use. CASE SUMMARY: A 12-year-old girl with a history of wearing orthokeratology contact lenses and a 14-year-old girl with a history of wearing cosmetic contact lenses presented with ocular pain, injection, and decreased visual acuity. They were diagnosed as having acanthamoeba keratitis based on slit lamp examination, confocal microscopy and culture. After the patients were treated with polyhexamethylene biguanide (PHMB) and chlorhexidine, corneal epithelial defect and erosion occurred. Use of chlorhexidine was stopped, and PHMB was used to treat patients and recovery of the corneal epithelium with improvement in symptoms of acanthamoeba keratitis was found. CONCLUSIONS: Using PHMB and chlorhexidine together in treating acanthamoeba keratitis increases the risk of corneal toxicity. Therefore, these drugs should be avoided in combination. |
| Key Words:
Acanthamoeba;Chlorhexidine;Human corneal keratocyte;Polyhexamethylene biguanide |
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