J Korean Ophthalmol Soc > Volume 54(6); 2013 > Article
Journal of the Korean Ophthalmological Society 2013;54(6):977-981.
DOI: https://doi.org/10.3341/jkos.2013.54.6.977    Published online June 15, 2013.
Two Cases of Intravitreal Ganciclovir Injection for Cytomegalovirus Retinitis.
Jung Bin Han, Seung Won Lee, Hyung Woo Kwak
Department of Ophthalmology, KyungHee University Medical Center, KyungHee University School of Medicine, Seoul, Korea. hwkwak@khu.ac.kr
유리체강내 ganciclovir 주입술을 이용한 거대세포바이러스망막염 치료 2예
Department of Ophthalmology, KyungHee University Medical Center, KyungHee University School of Medicine, Seoul, Korea
To report 2 cases of cytomegalovirus retinitis treated with intravitreal ganciclovir. CASE SUMMARY: A 29-year-old female (Case 1) who received immunosuppressive therapy with tacrolimus and mycophenolate mofetil for 3 months after pancreatic transplantation, was given an intravitreal Bevacizumab injection 4 times in each eye under the suspicion of bilateral central retinal vein occlusion. During follow-up, a new lesion with white opacification and multiple snowballs appeared in the left eye. Suspecting cytomegalovirus retinitis, we administered an intravitreal ganciclovir injection resulting in a decrease of white opacification and improvement of visual acuity. A 66-year-old male (Case 2) who was receiving treatment for general weakness and heart failure, presented with visual disturbance in both eyes. Fundoscopic examination revealed white opacification, multiple snowballs and retinal hemorrhage in the left eye; diagnostic vitrectomy was performed. Macular edema and subretinal fluid continued after the vitrectomy and the serologic testing revealed an IgG titer positive for cytomegalovirus, therefore, an intravitreal injection of ganciclovir was given. Macular edema and subretinal fluid decreased and visual acuity improved. CONCLUSIONS: Intravitreal ganciclovir can be an effective treatment option for the management of CMV retinitis.
Key Words: Cytomegalovirus retinitis;Ganciclovir;Intravitreal ganciclovir injection

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