J Korean Ophthalmol Soc > Volume 54(7); 2013 > Article
Journal of the Korean Ophthalmological Society 2013;54(7):1130-1134.
DOI: https://doi.org/10.3341/jkos.2013.54.7.1130    Published online July 15, 2013.
Macular Hole after Single Intravitreal Injection of Ranibizumab in a Patient with Age-Related Macular Degeneration.
Jong Min Kim, Jun Won Jang, Sung Eun Kyung, Moo Hwan Chang
Department of Ophthalmology, Dankook University Medical College, Cheonan, Korea. changmh@dankook.ac.kr
신생혈관성 나이관련황반변성 환자에서 1차 루센티스 안내주사 후 발생한 전층황반원공 1예
Department of Ophthalmology, Dankook University Medical College, Cheonan, Korea
To report a case of a full-thickness macular hole after a single intravitreal injection of ranibizumab in a patient with choroidal neovascularization associated with age-related macular degeneration. CASE SUMMARY: A 63-year-old woman presented to our department with gradually decreasing vision in her right eye. Best corrected visual acuity (BCVA) was measured as 0.7 in the right eye and 1.0 in the left eye. Examination of the macula showed a choroidal neovascularization associated with subretinal hemorrhage in the right eye. Optical coherence tomography (OCT) confirmed incomplete posterior vitreous detachment, subretinal hemorrhage and serous elevation. The patient subsequently received an intravitreal ranibizumab injection. After 1 month, the best corrected visual acuity in the right eye was decreased to 0.4, and fundus examination revealed posterior vitreous detachment and a macular hole. The patient underwent pars plana vitrectomy with internal limiting membrane peeling and fluid-air exchange, SF6 gas injection, phacoemulsification and posterior chamber intraocular lens implantation. Three months later, the macular hole had closed completely and best visual acuity was 1.0. CONCLUSIONS: Although the occurrence of a full-thickness macular hole after intravitreal ranibizumab injection is uncommon, physicians should be well acquainted with this complication.
Key Words: Intravitreal;Lucentis;Macular hole;Ranibizumab

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