The Effect of Ginkgo Biloba to Retinal Microcirculation.

Lee, Dong Joon; Ahn, Hee Bae; Rho, Sae Heun

Original Article

Journal of the Korean Ophthalmological Society 2002;43(8):1522-1527.
Published online August 1, 2002.

The Effect of Ginkgo Biloba to Retinal Microcirculation.

Dong Joon Lee, Hee Bae Ahn, Sae Heun Rho

Department of Ophthalmology, College of Medicine, Dong-A University, Pusan, Korea. shrho@donga.ac.kr

정상인에서 Ginkgo biloba 의 경구투여 후 시신경유두, 유두주위망막 및 황반부의 미세혈류 변화 관찰

이동준 ( Dong Joon Lee ) , 안희배 ( Hee Bae Ahn ) , 노세현 ( Sae Heun Rho )

Abstract

PURPOSE
We evaluated the microcircular changes of optic disc, peripapillary and macular area in healthysubjects who had taken Gingko biloba extract. METHODS: 10 healthy subjects (20 eyes) took Gingko biloba extract 40mg three times daily. Confocal scanning laser flowmetry (Heidelberg Retina Flowmetry, Heidelberg Engineering, Heidelberg, Germany) was used to measure the changes of microcirculation at before and after 2, 4 hours, 1 day, 1, 2, 3, 4 weeks. RESULTS: After administration of Gingko biloba extract, blood velocity, blood flow and blood volume in optic disc, peripapillary and macular area increased in all periods but statistically significant in 1 day, 1, 2, 3, 4 weeks except blood volume of macular area in 1 day. No side effects related to Gingko biloba extract were found. CONCLUSIONS: Gingko biloba extract increased microcircular blood velocity, flow, and volume in healthysubjects.

Key Words: Ginkgo biloba;Blood flow;Blood volume;Blood velocity