Cyclosporin A in High Risk Penetrating Keratoplasty.

Kim, Changkook; Tchah, Hungwon

Original Article

Journal of the Korean Ophthalmological Society 2001;42(8):1139-1142.
Published online August 1, 2001.

Cyclosporin A in High Risk Penetrating Keratoplasty.

Changkook Kim, Hungwon Tchah

Department of Ophthalmology, Asan Medical Center, College of Medicine Ulsan University, Seoul, Korea.

고위험군의 전층각막이식후 Cyclosporin A 의 효과

김창국(Chang Kook Kim),차흥원(Hung Won Tchah)

Abstract

PURPOSE
To conform the effectiveness of Cyclosporin(CsA) in penetrating keratoplasty(PKP), we compared the survival rate of grafts between CsA-used group and CsA-unused group(control group) in high risk patients. MATERIAL AND METHOD: High risk cornea was defined as vascularization in 3 or 4 quadrants, recurrent graft or corneal surface disease. We reviewed the 74 eyes(74 patients) which received penetrating keratoplasty with high risk cornea, and compared the survival rate between CsA-used group and control group. RESULT: Twenty-nine of the 74 patients were treated with CsA(17 patients with topical CsA and 12 with oral CsA ). The survival rate of CsA-used group was not superior to that of control group. CONCLUSION: CsA seems not to be effective in graft survival of high risk PKP.

Key Words: Cyclosporin A;Penetrating keratoplasty;High risk group