The Comparative Assessment of Filtering Bleb by Timing of subconjunctival Injection of Mitomycin-C in Glaucoma Filtering Surgery.

Lee, Dae Won; Chang, Moo Hwan; Lee, Jong Hoon

Original Article

Journal of the Korean Ophthalmological Society 1999;40(2):513-522.
Published online February 1, 1999.

The Comparative Assessment of Filtering Bleb by Timing of subconjunctival Injection of Mitomycin-C in Glaucoma Filtering Surgery.

Dae Won Lee, Moo Hwan Chang, Jong Hoon Lee

Department of Ophthalmology, College of Medicine, Dankook University.

녹내장 여과수술에서 Mitomycin-C(MMC)의 결막하주사 시기에 따른 여과포형성의 비교

이대원(Dae Won Lee),장무환(Moo Hwan Chang),이종훈(Jong Hoon Lee)

Abstract

In glaucoma filtering surgery, we conducted subconjunctival injection of Mitomycin-C(MMC) 12 hours before and after surgery, and examined histologic findings of the filtering bleb, and condition of the anterior chamber which ensued after the injection. We divided 15 full-grown rabbits into three groups, and for each group, administered subconjunctivally 0.1cc of 0.002%, 0.004%, and 0.008% MMC, respectively. The subconjunctival injection of MMC before surgery was given to the right eye and post-surgical injection to the left, and we examined the results 1, 2, 4, 7, and 14 days after the administration.In conclusion, subconjunctival injection of MMC 12 hours before glaucoma filtering surgery is shown to be more effective than the injection after the surgery.

Key Words: Mitomycin-C;Preoperative-subconjunctival injection;Postoperative-subconjunctival injection;Soaking;Filtering bleb