The Effect of Subconjunctival Injection of Liposome Encapsulated Cytarabine on Proliferation of Fibroblasts.

Seong, Gong Je; Hong, Young Jae; Park, Seong Jun

Original Article

Journal of the Korean Ophthalmological Society 1992;33(9):885-891.
Published online September 1, 1992.

The Effect of Subconjunctival Injection of Liposome Encapsulated Cytarabine on Proliferation of Fibroblasts.

Gong Je Seong, Young Jae Hong, Seong Jun Park

¹Department of Ophthalmology, Yonsei University College of Medicine, Korea.
²Department of Ophthalmology, Yonsei University Wonju College of Medicine, Korea.

결막하주사한 liposome 포장 cytarabine 이 섬유아세포 증식에 미치는 효과

성공제(Gong Je Seong),홍영재(Young Jae Hong),박성준(Seong Jun Park)

Abstract

To know the effect of subconjunctival injection of liposome encapsulated cytarabine on proliferation of conjunctival fibroblasts, the conjunctiva was isolated at 180 degrees from the injection site 3 days after subconjunctival injection of the normal saline (control), cytarabine, liposome encapsulated cytarabine, and 1 day after injection of cytarabine, and then those were inoculated in the culture media of fibroblasts. In the case of 3 days after injection of cytarabine, there was 49% and 42% inhibition of proliferation of conjunctival fibroblasts compared with the control respectively. Therefore, the authors concluded that the liposome encapsulated cytarabine is effective on inhibition of proliferation of conjunctival fibroblasts and reduces the frequencies of subconjunctival injection compared with the cytarabine itself.

Key Words: Cytarabine;Fibroblast;Liposome encapsulated cytarabine