Journal of the Korean Ophthalmological Society 1992;33(7):719-723.
Published online July 1, 1992.
Botulinum-Induced Changes in Orbicularis Oculi Muscle.
Sang Ki Ahn, Jae Chan Kim, Kyung Hwan Shyn
Department of Ophthalmology, Chung Ang University, College of Medicine, Seoul, Korea.
Botulinum Toxin 주사로 인한 안윤근의 병리조직학적 변화
안상기(Sang Ki Ahn),김재찬(Jae Chan Kim),신경환(Kyung Hwan Shyn)
A 60-year-old woman who had essential blepharospasm was treated with botulinum toxin A (two injections) around her orbital regions. The patient experienced reduction of blepharospsam for one month. But involutional blepharoptosis, brow ptosis and dermatochalasis had remained, so she underwent blepharoplasty. The resected orbicularis muscle during blepharoplasty was examined histopathologically. It was suggested that nonselective atrophy of the orbicularis muscles was derived from the loss of the normal neurotrophic influence of nerve on muscle by the botulinum toxin A.
Key Words: Botulinum toxin A;Essential blepharospasm;Muscle atrophy

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