Double-blind Study on the Effect of lndomethacin(MS-15) Eye-drops on Mydriasis During Cataract Extraction.

Kim, Man Soo; Han, Tae Won; Kim, Jae Ho

Original Article

Journal of the Korean Ophthalmological Society 1987;28(5):989-993.
Published online May 1, 1987.

Double-blind Study on the Effect of lndomethacin(MS-15) Eye-drops on Mydriasis During Cataract Extraction.

Man Soo Kim, Tae Won Han, Jae Ho Kim

Department of Ophthalmology, Kangnam St. Mary's Hospital, Catholic University, Medical College, Seoul, Korea.

백내장 수술중 Indomethacin(R) 점안이 동공 축소억제에 미치는 영향

김만수(Man Soo Kim),김재호(Jae Ho Kim),한태원(Tae Won Han)

Abstract

We studied the effect of MS-15, a new ophthalmic non steroidal antiinflammatory agent (Indomethacin), on reducing pupillary constriction during cataract surgery. Prior to surgery 0.5% of ibuprofen lysinate or a placebo was instilled 7 times and the surgeon's normal regimen of mydriatics and cycloplegics was used. MS(R) 15(0.5% ibuprofen lysinate) was far more effective than the placebo in maintaining dilated pupil during the cataract surgery. The change of the pupillary diameter from the conjunctival incision to after lens cortex aspiration averaged 0.42mm in MS-15 treatment group and 0.98 mm in placebo group. The difference between two groups was statistically significant(0.001