J Korean Ophthalmol Soc > Volume 59(4); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(4):362-368.
DOI: https://doi.org/10.3341/jkos.2018.59.4.362    Published online April 15, 2018.
Comparison of the Efficacy of Topical Steroids after Trabeculectomy in Patients with Primary Open-angle Glaucoma.
Jun Young Ha, Tae Hee Lee, Mi Sun Sung, Sang Woo Park
1Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. exo70@naver.com
2Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
원발개방각녹내장 환자에서 섬유주절제술 후 점안 스테로이드 치료 효과 비교
하준영1⋅이태희1⋅성미선1⋅박상우1,2
전남대학교 의과대학 안과학교실1, 전남대학교 의생명연구원2
Correspondence:  Sang Woo Park,
Email: exo70@naver.com
Received: 2 November 2017   • Revised: 23 January 2018   • Accepted: 2 April 2018
Abstract
PURPOSE
To compare the surgical outcomes and intraocular pressure (IOP) reduction after trabeculectomy in patients with primary open-angle glaucoma (POAG) according to treatment with three different postoperative topical steroids. METHODS: A total of 84 eyes of 84 patients who had undergone trabeculectomy for POAG and were followed-up at least 1 year were included in this study. According to the postoperative topical steroid treatment, the patients were divided into three groups involving 0.5% loteprednol etabonate (LE), 1% rimexolone (RMX), and 1% prednisolone acetate (PDA). The mean IOP change, mean number of topical anti-glaucoma medication changes, 1-year success rate, and complication percentage were compared among the three groups. RESULTS: There were significant reductions in the IOP and number of anti-glaucoma medications during the postoperative 1-year follow-up in all of the groups (all, p < 0.05), but there were no differences among the three groups. Postoperative 1-year success rates (68.2% in the LE group, 67.0% in the RMX group, and 65.9% in the PDA group; p = 0.88) and complication percentages of trabeculectomy were not significantly different among the three groups. CONCLUSIONS: There were no statistical differences in the 1-year success rate, complication percentage, visual acuity, IOP, and number of anti-glaucoma medications among treatment regimens. LE and RMX were as effective and safe as PDA after trabeculectomy in patients with POAG.
Key Words: Primary open-angle glaucoma;Topical steroid;Trabeculectomy


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