| Treatment of Periorbital Infantile Capillary Hemangioma with Propranolol. |
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Jung Hoo Lee, Seung Hwan Jo, Jae Wook Yang |
1Department of Ophthalmology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. oculoplasty@gmail.com
2T2B Infrastructure Center for Ocular Disease, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. |
| 안와 주위에 발생한 유아 모세혈관종의 프로프라놀롤을 사용한 치료 |
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이정후1,2⋅조승환1,2⋅양재욱1,2 |
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인제대학교 의과대학 부산백병원 안과학교실1, 인제대학교 의과대학 부산백병원 안과질환 T2B 기반구축센터2 |
Correspondence:
Jae Wook Yang,
Email: oculoplasty@gmail.com
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Received: 14 December 2017 • Revised: 28 January 2018 • Accepted: 20 April 2018 |
| Abstract |
PURPOSE
To report the clinical results of systemic propranolol for infantile periorbital hemangiomas. METHODS: A retrospective analysis was performed on 11 patients who were treated with beta-blockers for cosmetic purposes or for those with an invalid visual axis from January 2010 to June 2017. A beta receptor blocker (propranolol) was administered at a dose of 2 mg/kg/day. The size of the lesion was analyzed using Image J software, version 1.47 (National Institutes of Health, Bethesda, MD, USA) at 1–2 months until the drug was discontinued after the initial treatment and discharge. We observed the occurrence of side effects such as hypoglycemia, nausea, and vomiting due to drug use. RESULTS: Of the 11 patients, 9 (82%) were female and 2 (18%) were male. The location of the capillary hemangioma was in the upper eyelid of eight eyes (72.7%) and in the lower eyelid of three eyes (27.3%). The mean duration of treatment was 6.2 months and the mean follow-up period was 8.3 months. In 11 patients (100%), the lesion size was reduced. A temporary allergic response was seen in one patient, but no adverse side effects were seen that involved life-threatening effects. CONCLUSIONS: Infantile hemangiomas may cause cosmetic problems and amblyopia when invading the visual axis, which may require active treatment. Oral beta-blocker therapy for infantile hemangiomas of the orbit was safe for months or longer, with adequate treatment and with little to no adverse effects. |
| Key Words:
Capillary hemangioma;Periorbital tumor;Propranolol |
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