| Poorly Differentiated Neuroendocrine Carcinoma of the Eyelid. |
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Kyuyeon Cho, Jeong Hee Kim, Dong Cheol Lee, Yeon Lim Suh, Kyung In Woo, Yoon Duck Kim |
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ydkimoph@skku.edu
2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
| 눈꺼풀에 발생한 저분화 신경내분비암 1예 |
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조규연1⋅김정희1⋅이동철1⋅서연림2⋅우경인1⋅김윤덕1 |
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성균관대학교 의과대학 삼성서울병원 안과학교실1, 성균관대학교 의과대학 삼성서울병원 병리학교실2 |
Correspondence:
Yoon-Duck Kim
Email: ydkimoph@skku.edu |
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Received: 29 March 2018 • Revised: 13 June 2018 • Accepted: 26 August 2018 |
| Abstract |
PURPOSE
To report a case of poorly differentiated neuroendocrine carcinoma of the eyelid. CASE SUMMARY: A 70-year-old male presented with a 5-month history of a right upper eyelid mass. The mass appeared as 1.2 × 1.2 cm on the right upper eyelid. A mass excision was performed under frozen section control. The tumor was completely excised with a safety margin clearance and an upper eyelid reconstruction was performed. Histopathological examination revealed a tumor composed of small atypical cells which showed a high nuclear/cytoplasm ratio, nuclear molding, and increased mitotic activity. Immunohistochemical examination revealed positive reactivity for Ki-67, synaptophysin, CD56, and negative reactivity for chromogranin, cytokeratin 20, and thyroid transcription factor-1. CONCLUSIONS: Primary neuroendocrine carcinoma of the eyelid is extremely rare, but the tumor has high malignancy and readily metastasizes. Poorly differentiated neuroendocrine carcinoma should be considered in the differential diagnosis of a rapidly growing eyelid mass. |
| Key Words:
Eyelid;Merkel cell carcinoma;Poorly differentiated neuroendocrine carcinoma;Small cell carcinoma;Small cell neuroendocrine carcinoma |
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