J Korean Ophthalmol Soc > Volume 59(9); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(9):881-886.
DOI: https://doi.org/10.3341/jkos.2018.59.9.881    Published online September 15, 2018.
A Case of Punctate Inner Choroidopathy Followed by Multiple Evanescent White Dot Syndrome.
Su Youn Suh, Jong Ho Park, Seung Min Lee, Sung Who Park, Ji Eun Lee, Ik Soo Byon
1Research Institute for Convergence of Biomedical Science and Technology, Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan, Korea. isbyon@pusan.ac.kr
2Medical Research Institute, Department of Ophthalmology, Pusan National University Hospital, Busan, Korea.
3Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, Korea.
점모양내측맥락막병증 환자에서 병발한 소실다발흰점증후군 1예
서수연1⋅박종호1⋅이승민1⋅박성후2,3⋅이지은2,3⋅변익수1,3
양산부산대학교병원 안과 의생명융합연구소1, 부산대학교병원 안과 의생명연구소2, 부산대학교 의학전문대학원 안과학교실3
Correspondence:  Ik Soo Byon,
Email: isbyon@pusan.ac.kr
Received: 12 April 2018   • Revised: 31 May 2018   • Accepted: 28 August 2018
Abstract
PURPOSE
To report a delayed onset of multiple evanescent white dot syndrome in a patient with punctate inner choroidopathy. CASE SUMMARY: A 23-year-old female complained about sudden visual loss in the right eye. Best-corrected visual acuity (BCVA) was 20/100 in the right eye and 20/20 in the left eye. In fundus examination and optical coherence tomographic images, subfoveal choroidal neovascularization (CNV) with hemorrhage was observed in the right eye, accompanied by multiple lesions of atrophic pigmentation on the posterior pole in both eyes. We diagnosed the patient as punctate inner choroidopathy (PIC) and CNV in the right eye, and treated her using three monthly intravitreal injections of bevacizumab (Avastin®, Roche, Basel, Switzerland; 1.25 mg/0.05 mL). The CNV regressed and the BCVA improved to 20/20. Two years later, she complained of visual impairment in her left eye. The BCVA was 20/40. Fundus photography revealed numerous small white dots around the posterior pole and optic disc. Disruption of the photoreceptor layer was seen in optical coherence tomography images. Small white dots were observed as multiple hyperfluorescent dots in fluorescein angiography and hypofluorescent spots in indocyanine green angiography. An enlarged blind spot was observed in the visual field. We diagnosed her as multiple evanescent white dot syndrome (MEWDS). One month after systemic steroid treatment, the multiple white dots disappeared and the BCVA improved to 20/20. CONCLUSIONS: We determined that PIC and MEWDS, which belong to the white dot syndrome, could occur in a patient at different times.
Key Words: Multiple evanescent white dot syndrome;Punctate inner choroidopathy;White dot syndrome


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