J Korean Ophthalmol Soc > Volume 59(10); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(10):960-967.
DOI: https://doi.org/10.3341/jkos.2018.59.10.960    Published online October 15, 2018.
Association between Normal-tension Glaucoma and Allergic Rhinitis in a Korean Population-based Study.
Areum Jeong, Soon Cheol Cha
Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. sccha@ynu.ac.kr
정상안압녹내장과 알레르기비염과의 연관성: 제5기 국민건강영양조사 자료
영남대학교 의과대학 안과학교실
Correspondence:  Soon Cheol Cha,
Email: sccha@ynu.ac.kr
Received: 10 May 2018   • Revised: 4 July 2018   • Accepted: 28 September 2018
The purpose of this study was to investigate the association between normal-tension glaucoma (NTG) and allergic rhinitis in a population-based setting using data from the Korea National Health and Nutrition Exam Survey (2010–2012). METHODS: The authors selected a total of 8,614 participants aged 40 years and older for this study. All participants completed an ophthalmic examination required for diagnosis of NTG based on the International Society for Geographical and Epidemiological Ophthalmology criteria. An interview regarding nasal symptoms was also performed. The included participants were classified into NTG (n = 604) and control (n = 8,010) groups. The authors compared the groups in terms of prevalence of allergic rhinitis and identified risk factors of NTG. RESULTS: In NTG patients, allergic rhinitis prevalence was 29.1% (176/604), which was significantly higher than that of the control group (25.0%, 2,000/8,010; p = 0.023). There were significant associations between NTG and allergic rhinitis (odds ratio [OR]= 1.34, 95% confidence interval [CI] = 1.12–1.62, p = 0.002), even after adjusting for potential confounders (age, sex, diabetes, hypertension, number, of family members, household income quartile, frequency of eating out, and smoking status). In particular, patients with NTG aged 60–69 years, those aged 70–79 years, and those who were male had significantly higher ORs for prior allergic rhinitis compared with control subjects (OR = 1.62, 95% CI = 1.16–2.26, p = 0.005; OR = 1.52, 95% CI = 1.06–2.18, p = 0.024; and OR = 1.42, 95% CI = 1.10–1.83, p = 0.007, respectively). CONCLUSIONS: This study showed a significant association between NTG incidence and allergic rhinitis, especially in males and elderly patients (>60 years of age). These results suggested that allergic rhinitis may have a potential role in the development of NTG. Therefore, ophthalmologists and allergic rhinitis patients should remain vigilant to this potential risk factor.
Key Words: Allergic rhinitis;Korea National Health and Nutrition Exam Survey;Normal tension glaucoma

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