J Korean Ophthalmol Soc > Volume 59(12); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(12):1152-1159.
DOI: https://doi.org/10.3341/jkos.2018.59.12.1152    Published online December 15, 2018.
Long-term Results of Taking Anti-oxidant Nutritional Supplement in Intermediate Age-related Macular Degeneration.
Seul Ki Bang, Eung Suk Kim, Jong Woo Kim, Jae Pil Shin, Ji Eun Lee, Hyeong Gon Yu, Kuhl Huh, Seung Young Yu
1Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea. syyu@khu.ac.kr
2Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.
3Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea.
4Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, Korea.
5Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
6Blue Eye Center, Seoul, Korea.
중기 나이관련황반변성 환자에서 항산화영양제 복용 후 장기 관찰 결과
경희대학교 의과대학 경희대학교병원 안과학교실1, 건양대학교 의과대학 김안과병원 안과학교실2, 경북대학교 의과대학 안과학교실3, 부산대학교 의과대학 안과학교실4, 서울대학교 의과대학 안과학교실5, 푸른세상안과의원6
Correspondence:  Seung-Young Yu
Email: syyu@khu.ac.kr
Received: 21 June 2018   • Revised: 5 October 2018   • Accepted: 23 November 2018
We prospectively investigated clinical changes and long-term outcomes after administration of the drugs recommended by the Age-Related Eye Disease Study-2 to patients with intermediate age-related macular degeneration (AMD). METHODS: This prospective multicenter study enrolled 79 eyes of 55 patients taking lutein and zeaxanthin. The primary endpoint was contrast sensitivity; this was checked every 12 months for a total of 36 months after treatment commenced. The secondary endpoints were visual acuity, central macular thickness, and drusen volume; the latter two parameters were assessed using spectral domain optical coherence tomography. RESULTS: The mean patient age was 72.46 ± 7.16 years. Contrast sensitivity gradually improved at both three and six cycles per degree. The corrected visual acuity was 0.13 ± 0.14 logMAR and did not change significantly over the 36 months. Neither the central macular thickness nor drusen volume changed significantly. CONCLUSIONS: Contrast sensitivity markedly improved after treatment, improving vision and patient satisfaction. Visual acuity, central retinal thickness, and drusen volume did not deteriorate. Therefore, progression of AMD and visual function deterioration were halted.
Key Words: Age-Related Eye Disease Study (AREDS)-2 formula;Contrast sensitivity;Drusen volume;Intermediate age-related macular degeneration (AMD)

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