J Korean Ophthalmol Soc > Volume 60(3); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(3):233-238.
DOI: https://doi.org/10.3341/jkos.2019.60.3.233    Published online March 15, 2019.
The Relationship between Allergic Conjunctivitis due to Brimonidine and Systemic Allergic Disease in Glaucoma Patients.
Jongwook Han, Wungrak Choi, Won Seok Lee, Hyoung Won Bae, Chan Yun Kim, Gong Je Seong
1Institute of Vision Research, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. GJSEONG@yuhs.ac
2Institute of Vision Research, Department of Ophthalmology, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
전신 알레르기 질환과 브리모니딘 점안으로 인한 알레르기결막염의 관계
한종욱1⋅최웅락1⋅이원석1⋅배형원2⋅김찬윤2⋅성공제1
연세대학교 의과대학 강남세브란스병원 안과학교실 시기능 개발연구소1, 연세대학교 의과대학 신촌세브란스병원 안과학교실 시기능 개발연구소2
Correspondence:  Gong Je Seong,
Email: GJSEONG@yuhs.ac
Received: 24 May 2018   • Revised: 8 August 2018   • Accepted: 19 February 2019
Abstract
PURPOSE
Several different topical eye drop medications are used to lower the intraocular pressure of glaucoma patients. Among them, 0.1% brimonidine tartrate is commonly used and accompanies allergic conjunctivitis as a side effect. This study determined the correlation between the severity of allergic conjunctivitis arising from brimonidine eye drop use and systemic allergic disease. METHODS: A case report study of 63 selected patients diagnosed with open-angle glaucoma or normal-tension glaucoma, and developing allergic conjunctivitis due to brimonidine usage was conducted. The study surveyed patients with newly diagnosed allergic conjunctivitis in terms of allergic rhinitis, asthma, and urticaria symptoms, and a slit lamp examination was used to determine the severity of allergic conjunctivitis in the clinic, using a novel scoring system to establish correlations of interest. RESULTS: There was no correlation between asthma and the severity of allergic conjunctivitis (r = −0.095, p = 0.461). Allergic rhinitis showed no significant correlation with the severity of allergic conjunctivitis (r = 0.117, p = 0.361), and urticaria displayed no significant correlation with allergic conjunctivitis (r = −0.110, p = 0.389). We found no correlation in glaucoma patients between brimonidine eye drop use and the severity of allergic conjunctivitis. CONCLUSIONS: Systemic allergic disease was not related to the severity of allergic conjunctivitis arising from the use of brimonidine eye drops, indicating that the use of these eye drops can effectively lower intra-ocular pressure even if the patient suffers from systemic allergic disease.
Key Words: Allergic;Brimonidine;Conjunctivitis;Glaucoma


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