J Korean Ophthalmol Soc > Volume 60(3); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(3):239-245.
DOI: https://doi.org/10.3341/jkos.2019.60.3.239    Published online March 15, 2019.
Comparison of Efficacy and Sensation of Instillation between 0.05% Cyclosporine Nanoemulsion and Microemulsion Type.
Eun Hae Shin, Dong Hui Lim, Chan Min Yang, Tae Young Chung
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. taeyoung15.chung@samsung.com
2Department of Preventive Medicine, Graduate School, The Catholic University of Korea, Seoul, Korea.
0.05% 사이클로스포린 마이크로에멀젼과 나노에멀젼에서 치료 후 건성안 지표 및 점안감 비교
신은혜1⋅임동희1,2⋅양찬민1⋅정태영1
성균관대학교 의과대학 삼성서울병원 안과학교실1, 가톨릭대학교 예방의학교실2
Correspondence:  Tae-Young Chung
Email: taeyoung15.chung@samsung.com
Received: 19 April 2018   • Revised: 26 May 2018   • Accepted: 19 February 2019
Abstract
PURPOSE
To evaluate and compare the efficacy and sensation of instillation between 0.05% cyclosporine nanoemulsion group and microemulsion group. METHODS: This is a double-blind, prospective randomized clinical trial. Patients had 2 weeks of wash-out period before the study. They were randomly assigned to either nanoemulsion group or microemulsion group and treated with each group's cyclosporine eye drop. Artificial eye drop and topical steroid were used together according to severity of dryness of cornea. We checked every patient's Break-up time (BUT), Schirmer test, Staining Score and Ocular surface disease index (OSDI) on baseline, 1 month and 3 months after. Patients also self-checked frequency of use of artificial eye drop and topical steroid. Sensation of instillation was also checked. RESULTS: Both nanoemulsion eye-drop and microemulsion eye-drop improved BUT, Schirmer test, Staining Score and OSDI throughout 12 weeks. The nanoemulsion type reduced OSDI significantly compared to the microemulsion type. The mean frequency of use of artificial tear and topical steroid was similar in both groups. Foreign body sense score was higher in microemulsion group. CONCLUSIONS: 0.05% cyclosporine nanoemulsion type has simillar efficacy and subjectively less foreign body sensation.
Key Words: Cyclosporine;Dry eye syndromes;Microemulsion;Nanoemulsion


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