A Case of Clozapine-induced Corneal and Lenticular Pigmentation.

An, Ji Seon; Lee, Young Mi; Kwag, Joo Young; Hyun, Joo; Choi, Jin Seok; Pak, Kyu Hong; Chung, Sung Kun

doi:2019.60.3.276

J Korean Ophthalmol Soc > Volume 60(3); 2019 > Article

Case Report

Journal of the Korean Ophthalmological Society 2019;60(3):276-279.
DOI: https://doi.org/10.3341/jkos.2019.60.3.276 Published online March 15, 2019.

A Case of Clozapine-induced Corneal and Lenticular Pigmentation.

Ji Seon An, Young Mi Lee, Joo Young Kwag, Joo Hyun, Jin Seok Choi, Kyu Hong Pak, Sung Kun Chung

¹Saevit Eye Hospital, Goyang, Korea. eyekun@gmail.com
²Department of Pharmacy, Saevit Eye Hospital, Goyang, Korea.

클로자핀 복용으로 유발된 각막 및 수정체 색소침착 1예

안지선¹⋅이영미²⋅곽주영¹⋅현 주¹⋅최진석¹⋅박규홍¹⋅정성근¹

새빛안과병원¹, 새빛안과병원 약제실²

Correspondence: Sung Kun Chung,
Email: eyekun@gmail.com

Received: 30 August 2018 • Revised: 7 November 2018 • Accepted: 19 February 2019

Abstract

PURPOSE
To report a case of corneal and lenticular pigmentation after prolonged clozapine therapy. CASE SUMMARY: A 56-year-old male visited our hospital with a progressive decline in vision that affected both eyes. He had a history of schizophrenia. He was being treated with 200 mg clozapine and 1 mg lorazepam daily, and had been treated with clozapine for 5 years. At the first visit, his best-corrected-visual acuity was 20/32 in both eyes. Slit lamp examination of the corneas showed bright, fine, grayish-brown deposits on the endothelium, and on dilation, bilateral central stellate opacity of the anterior portion of the lens capsule was revealed. CONCLUSIONS: Clozapine may induce corneal and lenticular pigmentation and thus may lead to a decline in vision. Patients on long-term clozapine therapy should be considered for regular ophthalmic review.

Key Words: Clozapine;Corneal pigmentation;Lenticular pigmentation