J Korean Ophthalmol Soc > Volume 60(9); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(9):821-828.
DOI: https://doi.org/10.3341/jkos.2019.60.9.821    Published online September 15, 2019.
Effectiveness of Cyclosporine-steroid Treatment after Cataract Surgery according to Dry Eye Severity.
Jae Yeong Park, Sang Cheol Yang, Young Min Park, Ji Eun Lee, Choul Yong Park, Jong Soo Lee
1Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. jongsool@pusan.ac.kr
2Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
3Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
4Department of Ophthalmology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
건성안의 정도에 따른 백내장수술 후 싸이클로스포린과 스테로이드 점안액의 병합 치료 효과
박재영1 · 양상철1 · 박영민2 · 이지은3 · 박철용4 · 이종수1
부산대학교 의학전문대학원 부산대학교병원 안과학교실1, 경상대학교 의학전문대학원 창원경상대학교병원 안과학교실2, 부산대학교 의학전문대학원 양산부산대학교병원 안과학교실3, 동국대학교 의과대학 동국대학교 일산병원 안과학교실4
Correspondence:  Jong Soo Lee,
Email: jongsool@pusan.ac.kr
Received: 7 February 2019   • Revised: 5 March 2019   • Accepted: 16 August 2019
Abstract
PURPOSE
To evaluate the effectiveness of topically administered 0.05% cyclosporine combined with a topical steroid in the early postoperative period after cataract surgery, and to compare the therapeutic efficacy according to the severity of dry eye. METHODS: One hundred and fifty-six patients who underwent unilateral cataract surgery and received topical cyclosporine 0.05% for 8 weeks combined with a fluorometholone 0.1% steroid for 4-weeks were classified into three groups according to preoperative dry eye level: the control group, non-dry eye (n = 78); group 1, level I dry eye (n = 38); and group 2, level II dry eye (n = 40). The best-corrected distance visual acuity, intraocular pressure, dry eye symptom questionnaire (ocular surface disease index), tear film break-up time (TBUT), and Schirmer test-I (STI) were evaluated. RESULTS: The preoperative score of dry eye symptoms improved significantly at one week postoperatively and continued to improve until postoperative 8-weeks in all groups, especially in group 2 compared with the control. Groups 1 and 2 showed significant improvement in the TBUT at one week, four weeks, and eight weeks postoperatively, compared to eight weeks postoperatively in the control; Group 2, especially, showed significant improvement in TBUT. There was no difference in STI value after cyclosporine-steroid treatment in the control group; however, a significant difference was observed at four weeks postoperatively in dry eyes. No significant differences in STI results were observed among the three groups. CONCLUSIONS: Use of topical cyclosporine 0.05% combined with a topical fluorometholone 0.1% steroid after cataract surgery is more effective in dry eyes level II than in non-dry eyes, especially those with TBUT and dry eye symptoms at eight weeks postoperatively.
Key Words: Cataract surgery;Cyclosporine;Dry eye syndrome


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