J Korean Ophthalmol Soc > Volume 60(12); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(12):1169-1175.
DOI: https://doi.org/10.3341/jkos.2019.60.12.1169    Published online December 15, 2019.
Effects of Platelet-rich Plasma on Ocular Surface in Patients with Dry Eye Syndrome: Clinico-experimental Analysis.
Jae Uk Jung, Sang Hee Lee, Hong Kyun Kim
1Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, Korea. okeye@knu.ac.kr
2Cheil Eye Hospital, Daegu, Korea.
안구건조증에서 자가 혈소판 풍부 혈장이 안구표면에 미치는 영향: 임상 및 실험 분석
정재욱1 · 이상희2 · 김홍균1
경북대학교 의과대학 안과학교실1, 제일안과병원2
Correspondence:  Hong Kyun Kim,
Email: okeye@knu.ac.kr
Received: 12 July 2019   • Revised: 27 August 2019   • Accepted: 6 December 2019
Abstract
PURPOSE
To evaluate the effect of platelet rich plasma (PRP) on ocular surface damage caused by hyperosmotic conditions using retrospective clinical and experimental analyses. METHODS: Eighty eyes of moderate dry eye syndrome patients who had no responses using conventional treatments were included in the study. Before and 1, 3, and 6 months after the use of autologous PRP, the visual acuity, intraocular pressure, tear break-up time (TBUT), ocular staining score (OSS), and ocular surface disease index (OSDI) were compared. The changes in inflammatory factors of ocular surface cells were analyzed using a corneo-limbal epithelial cell culture and a hyperosmotic stress experimental model. RESULTS: Using retrospective clinical analyses, in 64 eyes (80%) after the use of autologous PRP, the symptom scores and symptoms were significantly reduced in the OSDI questionnaire when compared with the symptom scores and symptoms before treatment. The TBUT and OSS, which were objective indicators showed a significant increase of TBUT and significant decrease of OSS in 68 eyes (85%) and 72 eyes (90%), respectively. The expression of inflammatory factors such as interleukin-1, tumor necrosis factor-α, metalloproteinase (MMP)-1, and MMP-3 decreased in corneo-limbal epithelial cells under hyperosmotic conditions when PRP was added. CONCLUSIONS: The use of autologous PRP showed significant improvement before and after treatment in the TBUT, OSS, symptom scores and symptoms, and OSDI. In addition, anti-inflammatory effects were demonstrated in hyperosmotic models simulating dry eye syndrome. Therefore, autologous PRP could be used effectively for the treatment of moderate dry eye syndrome.
Key Words: Dry eye syndromes;Inflammatory factors;Platelet-rich plasma


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