J Korean Ophthalmol Soc > Volume 57(4); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(4):614-622.
DOI: https://doi.org/10.3341/jkos.2016.57.4.614    Published online April 15, 2016.
RNFL and Ganglion Cell Complex Thickness in Normal Hemifield According to the Severity of Glaucoma.
Eun Hee Hong, Yong Un Shin, Han Woong Lim, Min Ho Kang, Hee Yoon Cho, Mincheol Seong
Department of Ophthalmology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. goddns76@hanmail.net
반시야 결손 녹내장안의 중증도에 따른 정상 반시야 신경섬유층 및 신경절세포층 두께 비교
홍은희⋅신용운⋅임한웅⋅강민호⋅조희윤⋅성민철
한양대학교 의과대학 한양대학교구리병원 안과학교실
Correspondence:  Mincheol Seong
Received: 10 December 2015   • Revised: 24 February 2016   • Accepted: 21 March 2016
Abstract
PURPOSE
To analyze the thickness of the circumpapillary retinal nerve fiber layer (cRNFL) and macular ganglion cell complex (mGCC) in apparently normal hemifield areas of glaucomatous eyes with superior or inferior visual hemifield defects according to their severity compared with the same hemifield of normal eyes using Topcon 3D spectral-domain optical coherence tomography (SD-OCT). METHODS: The present study included 90 normal eyes and 90 glaucomatous eyes with superior or inferior visual hemifield defects that underwent cRNFL and mGCC imaging using 3D SD-OCT. The cRNFL and mGCC parameters were compared between normal hemifield in glaucomatous eyes and the same hemifield in normal eyes. The mean deviation (MD) parameters (Mild: MD > -6 dB, 54 eyes; Moderate: -6 dB ≥ MD ≥ -12 dB, 60 eyes; Severe: MD < -12 dB, 30 eyes) in glaucomatous eyes were also compared between the 3 severity groups. RESULTS: The average hemifield cRNFL thickness was 93.6 ± 24.2 µm and 118.1 ± 14.1 µm in superior normal hemifield of glaucomatous eyes and controls, respectively, and 107.8 ± 19.1 µm and 124.9 ± 17.1 µm in inferior normal hemifield of glaucomatous eyes and controls, respectively. mGCC thickness was 95.8 ± 5.9 µm and 103.5 ± 7.7 µm in superior normal hemifield of glaucomatous eyes and controls, respectively, and 93.4 ± 8.2 µm and 104.5 ± 8.2 µm in inferior normal hemifield of glaucomatous eyes and controls, respectively (all p < 0.05). The thickness parameters were decreased in normal hemifield of glaucomatous eyes, which significantly decreased according to the severity (MD) of visual field defect (all p < 0.01). CONCLUSIONS: The measurement of cRNFL and mGCC thickness in normal hemifield of glaucomatous eyes using SD-OCT is useful in detecting structural glaucomatous changes before visual field defects appear.
Key Words: Circumpapillary retinal nerve fiber layer (cRNFL);Glaucoma;Hemifield defect;Macular ganglion cell complex (mGCC);Spectral-domain optical coherence tomography (SD-OCT)


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