J Korean Ophthalmol Soc > Volume 57(4); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(4):667-671.
DOI: https://doi.org/10.3341/jkos.2016.57.4.667    Published online April 15, 2016.
A Case of Anterior Migration of Fragmented Dexamethasone Intravitreal Implant.
Byung Jae Kim, Seong Jae Kim, Yong Seop Han, Seong Wook Seo, Jong Moon Park, Ji Myong Yoo, In Young Chung
1Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. in0chung@hanmail.net
2Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea.
덱사메타존 유리체강내 삽입물 주입 후 발생한 분절화 및 전방 내 이동 1예
경상대학교 의학전문대학원 안과학교실1, 경상대학교 건강과학연구원2
Correspondence:  In Young Chung
Received: 27 February 2015   • Revised: 10 September 2015   • Accepted: 30 December 2015
To report a case of fragmentation and anterior migration occurred after dexamethasone intravitreal implant (Ozurdex®, Allergan, Irvine, CA, USA) injection in a branch retinal vein occlusion patient. CASE SUMMARY: A 66-year-old male was referred for blurred vision. He received cataract surgery in 1986 and was diagnosed with central retinal vein obstruction in 2011 in the right eye. For treatment of macular edema, dexamethasone intravitreal implant was performed in the right eye. One week after implantation, a fragment of the dexamethasone implant migrated to the anterior chamber with corneal edema and surgical removal was performed immediately. One day after removal, the remaining fragmented implant migrated to the anterior chamber and corneal edema still existed. The fragmented implant was removed with anterior chamber irrigation. After removal, corneal edema improved and visual acuity was recovered. CONCLUSIONS: Anterior migrated dexamethasone implant could induce corneal complications, such as corneal edema and corneal decompensation and might lower the corneal endothelial cell even if immediately removed. We report a case of corneal edema, which was induced by anterior migration of a fragmented dexamethasone implant and recovered with immediate surgical removal.
Key Words: Anterior chamber migration;Corneal edema;Dexamethasone intravitreal implant;Fragmentation;Ozurdex®

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