Two Cases of External Ophthalmoplegia after Vincristine Treatment in Childhood.

Lee, Dong Hyun; Jung, Jae Ho

doi:2016.57.7.1176

J Korean Ophthalmol Soc > Volume 57(7); 2016 > Article

Case Report

Journal of the Korean Ophthalmological Society 2016;57(7):1176-1179.
DOI: https://doi.org/10.3341/jkos.2016.57.7.1176 Published online July 15, 2016.

Two Cases of External Ophthalmoplegia after Vincristine Treatment in Childhood.

Dong Hyun Lee, Jae Ho Jung

Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. jungjaeho@pusan.ac.kr

소아에서 빈크리스틴 사용 후 발생한 외안근 마비 2예

이동현⋅정재호

부산대학교 의학전문대학원 양산부산대학교병원 안과학교실

Abstract

PURPOSE
To report 2 cases of extraocular muscle paresis with ptosis after vincristine treatment in childhood with acute leukemia. CASE SUMMARY: A 4-year-old girl with acute lymphoblastic leukemia experienced diplopia, esotropia and bilateral ptosis after intravenous vincristine treatment. Ptosis improved after two weeks of pyridoxine treatment with vincristine reduction. After 2 months, left abduction defect and ptosis completely disappeared with pyridoxine treatment. A 23-month-old boy with acute lymphoblastic leukemia had bilateral ptosis with worsening pre-existing infantile esotropia after intravenous vincristine treatment. Bilateral ptosis resolved and esotropia improved after vincristine reduction with pyridoxine treatment for 2 months. CONCLUSIONS: We observed extraocular muscle paresis and ptosis after vincristine treatment for acute leukemia in pediatric patients. Physicians should be suspicious of toxic neuropathy related to vincristine treatment when patients have extraocular ophthalmoplegia, and physicians should know that vincristine reduction with pyridoxine supplement may be helpful.

Key Words: Ophthalmoplegia;Ptosis;Vincristine