Solitary Neurofibroma Occurred on the Eyelid Margin without Neurofibromatosis: A Case Report.

Kang, Yeon Soo; Choi, Won; Kim, Ga Eon; Yoon, Kyung Chul

doi:2017.58.2.222

J Korean Ophthalmol Soc > Volume 58(2); 2017 > Article

Case Report

Journal of the Korean Ophthalmological Society 2017;58(2):222-225.
DOI: https://doi.org/10.3341/jkos.2017.58.2.222 Published online February 15, 2017.

Solitary Neurofibroma Occurred on the Eyelid Margin without Neurofibromatosis: A Case Report.

Yeon Soo Kang, Won Choi, Ga Eon Kim, Kyung Chul Yoon

¹Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@jnu.ac.kr
²Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.

신경섬유종증 없이 단독으로 눈꺼풀테에 발생한 신경섬유종 1예

강연수¹⋅최 원¹⋅김가언²⋅윤경철¹

전남대학교 의과대학 안과학교실¹, 전남대학교 의과대학 병리학교실²

Correspondence: Kyung Chul Yoon,
Email: kcyoon@jnu.ac.kr

Received: 28 July 2016 • Revised: 16 November 2016 • Accepted: 14 January 2017

Abstract

PURPOSE
We report a rare case of solitary neurofibroma on the eyelid margin without neurofibromatosis. CASE SUMMARY: A 46-year-old male presented with a well-define small nodular lesion on the right upper eyelid margin that had not changed for 10 years. Surgical excision and biopsy were performed. Histological examination showed spindle-shaped cells in the fibrous stroma on hematoxylin & eosin staining, and immunohistochemical staining revealed S-100 protein-positive cells. Dermatologic, neurologic, and genetic evaluations showed no evidence of systemic neurofibromatosis. Six months after operation, there was no evidence of local recurrence. CONCLUSIONS: To the best of our knowledge, this is the first case of solitary neurofibroma involving the eyelid margin without neurofibromatosis in Korea. Neurofibroma should be considered in a differential diagnosis of eyelid mass and can be successfully managed with surgical excision.

Key Words: Eyelid mass;Neurofibroma;Neurofibromatosis