J Korean Ophthalmol Soc > Volume 58(4); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(4):415-419.
DOI: https://doi.org/10.3341/jkos.2017.58.4.415    Published online April 15, 2017.
Prognostic Factors of Neovascular Glaucoma in Eyes with Treated Proliferative Diabetic Retinopathy.
Ji Hyun Lee, Eun Yeong Kim, Tai Kyong Kim, Hye Young Shin, Su Young Kim, Young Chun Lee, Mee Yon Lee
Department of Ophthalmology and Visual Science, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea. deenie@daum.net
치료된 증식당뇨망막병증에서 신생혈관녹내장 발생의 예측인자
이지현⋅김은영⋅김태경⋅신혜영⋅김수영⋅이영춘⋅이미연
가톨릭대학교 의과대학 의정부성모병원 안과 및 시과학교실
Correspondence:  Mee Yon Lee,
Email: deenie@daum.net
Received: 8 December 2016   • Revised: 15 February 2017   • Accepted: 27 March 2017
Abstract
PURPOSE
To evaluate the factors that are significant in progression to neovascular glaucoma in patients with proliferative diabetic retinopathy. METHODS: In this retrospective analysis, we reviewed the medical records of 52 patients who were first diagnosed with proliferative diabetic retinopathy from March 2014 to March 2016. We compared diabetes mellitus period, HbA1c, chronic diseases such as hypertension, hyperlipidemia, and kidney disease, insulin treatments, blood urea nitrogen, blood creatinine, glomerular filtration rate, urine albumin, dialysis, corrected visual acuity at the first visit, traction membrane sign of the retina at the first visit, vitreous hemorrhage and preretinal hemorrhage in each group and then investigated the prognostic factors of neovascular glaucoma. RESULTS: A total of 52 patients were included in the investigation, 12 patients (23.08%) were diagnosed with iris neovascularization and 4 patients (7.69%) developed neovascular glaucoma. The patients without iris neovascularization were defined as Group I, those with iris neovascularization as Group II, and those with neovascular glaucoma as Group III. The diabetes mellitus period was significantly longer in Group II (10.88 ± 7.14 years) and in Group III (11.75 ± 8.61 years) than Group I (8.30 ± 5.25 years) (p-value 0.41, 0.032, respectively). The HbA1c level was 9.59 ± 2.23 in Group II and 9.27 ± 2.54 in Group I. There was no significant difference between the two groups (p = 0.721). However, HbA1c was significantly higher in Group III (11.55 ± 0.21) than Group I (p-value 0.048). CONCLUSIONS: A long diabetes mellitus period and high HbA1c level have a significant effect on the progression to neovascular glaucoma in patients with proliferative diabetic retinopathy. This information could be useful for predicting and preventing the prognosis of patients.
Key Words: Diabetes mellitus;Hb1AC;Neovascular glaucoma;Proliferative diabetic retinopathy


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