Factors Influencing the Effect of the Intravitreal Bevacizumab Injection in Patients with Central Serous Chorioretinopathy.

Kweon, Eui Yong

doi:2014.55.3.391

J Korean Ophthalmol Soc > Volume 55(3); 2014 > Article

Original Article

Journal of the Korean Ophthalmological Society 2014;55(3):391-395.
DOI: https://doi.org/10.3341/jkos.2014.55.3.391 Published online March 15, 2014.

Factors Influencing the Effect of the Intravitreal Bevacizumab Injection in Patients with Central Serous Chorioretinopathy.

Eui Yong Kweon

Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea. key@jbnu.ac.kr

중심장액맥락망막병증 환자에서 유리체강내 베바시주맙 주입술의 치료 효과에 영향을 주는 요인

권 의 용

Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea

Abstract

PURPOSE
To evaluate the factors influencing the effect of the intravitreal bevacizumab injection in patients with central serous chorioretinopathy. METHODS: We performed a retrospective review of the medical records of 54 patients (56 eyes) who had been symptomatic for more than 3 months with central serous chorioretinopathy (CSC), who had undergone intravitreal bevacizumab injection and been on regular follow-up for at least 6 months. RESULTS: Responders were 34 eyes (60.7%) and non-responders were 22 eyes (39.3%). The leaking points of the non-responder group were multiple and located more centrally than that of the responder group on fluorescein angiography (FA) (p = 0.01, p = 0.044). In addition, non-responder group showed cystoid macular edema on optical coherence tomography (OCT) as compared with responder group (p = 0.042). CONCLUSIONS: CSC with multiple, centrally located leaks on FA or cystoid macular edema on OCT was ineffective or recurrent with intravitreal bevacizumab injection.

Key Words: Bevacizumab;Central serous chorioretinopathy