J Korean Ophthalmol Soc > Volume 55(4); 2014 > Article
Journal of the Korean Ophthalmological Society 2014;55(4):493-497.
DOI: https://doi.org/10.3341/jkos.2014.55.4.493    Published online April 15, 2014.
Clinical Efficacy of Polyhexamethylene Biguanide Lid Scrub on Demodex Blepharitis.
Jun Hyung Moon, Jae Chan Kim
Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. Jck50ey@kornet.net
데모덱스 안검염 환자에서 폴리헥사메틸렌 비구아니드를 이용한 안검 세척의 치료효과
문준형⋅김재찬
Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea
Abstract
PURPOSE
To evaluate the treatment efficacy of polyhexamethylene biguanide (PHMB) lid scrub on Demodex blepharitis. METHODS: Thirty-one patients diagnosed with Demodex blepharitis were evaluated every 2 weeks during 8 weeks of lid scrub treatment with 0.4% PHMB. Patients underwent epilation of 4 eyelashes in each eye, and the number of Demodex lesions was counted. The patients answered questionnaires regarding ocular surface discomfort and underwent ophthalmologic exams including slit lamp and tear breakup time (TBUT). Compliance was recorded as 1 of 3 stages (good, moderate, poor). RESULTS: One patient was excluded for poor compliance. After PHMB lid scrub for 8 weeks, Demodex count was reduced in 28 of 30 patients (pre-PHMB 7.9 +/- 3.6 counts, post-PHMB 2.2 +/- 2.4 counts, p < 0.01). In addition, TBUT showed a statistically significant increase after PHMB lid scrub (pre-PHMB 2.7 +/- 0.8 seconds, post-PHMB 3.4 +/- 0.9 seconds, p < 0.01). Ocular surface disease index (OSDI) score was reduced in 28 of 30 patients (pre-PHMB 22.0 +/- 10.7 points, post-PHMB 7.4 +/- 6.0 points, p < 0.01). CONCLUSIONS: Eight weeks of treatment with polyhexamethylene biguanide lid scrub on Demodex blepharitis had good treatment efficacy for reducing Demodex counts and OSDI scores and increasing TBUT.
Key Words: Demodex blepharitis;Polyhexamethylene biguanide


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