| Comparision between Simultaneous Intracameral and Intravitreal Injection and Intravitreal Injection of Bevacizumab in Neovascular Glaucoma. |
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Hyoun Do Huh, Yong Seop Han, In Young Chung, Seong Wook Seo, Jong Moon Park, Ji Myong Yoo, Seong Jae Kim |
1Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. Maya12kim@naver.com
2Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea. |
| 신생혈관녹내장에서 베바시주맙의 전방과 유리체내 동시 주입과 유리체내 단독 주입의 치료 효과 |
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허현도1⋅한용섭1,2⋅정인영1,2⋅서성욱1,2⋅박종문1,2⋅유지명1,2⋅김성재1,2 |
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Hyoun Do Huh, MD1, Yong Seop Han, MD, PhD1,2, In Young Chung, MD, PhD1,2, Seong Wook Seo, MD, PhD1,2, Jong Moon Park, MD, PhD1,2, Ji Myong Yoo, MD, PhD1,2, Seong Jae Kim, MD, PhD1,2 |
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| Abstract |
PURPOSE
To compare the clinical efficacy of simultaneous intracameral and intravitreal injection and intravitreal single injection of bevacizumab in patients with neovascular glaucoma (NVG). METHODS: The medical records of 43 eyes of 43 patients, who had treated with simultaneous intracameral and intravitreal injection (Group I) or intravitreal single injection (Group II) of bevacizumab 1.25 mg from January 2010 to December 2012, were retrospectively reviewed. The best corrected visual acuity (BCVA), intraocular pressure (IOP), regression time of new vessel in the iris (NVI) and anterior chamber angle (NVA), progression of peripheral anterior synechiae (PAS), and corneal parameters were measured preoperatively and one day, three days, 1 week, 1 month, and 3 months postoperatively. RESULTS: There was significant changes of IOP between the two groups at 1, 3 days postoperatively (p = 0.001, p < 0.001). The regression time of NVI and NVA in Group I was significantly faster than Group II (p = 0.026, p = 0.033). In the phakic eyes, regression time of NVI and NVA was significantly longer than aphakic and pseudophakic eyes in group II (p = 0.006, p = 0.005). Also, in the phakic NVG patients, the formation of PAS in Group I was significantly less than in Group II for the postoperative three months (p = 0.020). CONCLUSIONS: Simultaneous intravitreal and intracameral injection of bevacizumab seem to be more effective for the early lowering of IOP and regression of NVI and NVA, and inhibiting further PAS formation in NVG patients, especially in the phakic eyes. Therefore, simultaneous intracameral and intravitreal injection of bevacizumab may be considered as an adjunct to management of NVG in the phakic eyes. |
| Key Words:
Bevacizumab;Intraocular pressure;Lens;Neovascular glaucoma;Peripheral anterior synechiae |
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