J Korean Ophthalmol Soc > Volume 55(12); 2014 > Article
Journal of the Korean Ophthalmological Society 2014;55(12):1752-1757.
DOI: https://doi.org/10.3341/jkos.2014.55.12.1752    Published online December 15, 2014.
Efficacy of Topical Cyclosporine in Mild Dry Eye Patients Having Refractive Surgery.
Kun Wook Kang, Hong Kyun Kim
Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea. okeye@hanmail.net
경도의 안구건조증 환자에서 굴절교정수술 전후 0.05% 사이클로스포린 사용의 효과
강건욱⋅김홍균
Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea
Abstract
PURPOSE
To evaluate the efficacy of pre- and post-operative use of topical 0.05% cyclosporine A (CsA) in mild dry eye patients having refractive surgery. METHODS: This randomized prospective study included 40 patients with mild dry eye syndrome who were scheduled for laser in situ keratomileusis (LASIK). All patients were divided into 2 groups. Patients in the CsA group used both 0.1% sodium hyaluronate (HA) and 0.05% CsA from 2 weeks before to 8 weeks after the surgery, while patients in the control group used 0.1% HA only. Ocular surface disease index (OSDI), tear film break-up time (TF-BUT), Oxford Stain Score (OSS), and tear osmolarity were evaluated before surgery and 1, 4, and 8 weeks after surgery. RESULTS: TF-BUT was significantly longer in the CsA group at 1 and 4 weeks post-operatively (p = 0.024, p = 0.036) compared to the control group. Tear osmolarity was significantly lower in the CsA group at 1 week post-operatively (p = 0.004) compared to the control group. CONCLUSIONS: The pre- and post-operative use of topical 0.05% CsA is effective in alleviating dry eye symptom after LASIK in patients with dry eye syndrome.
Key Words: Cyclosporine;Dry eye syndrome;LASIK;Refractive surgery


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