Analysis of Aqueous Humor Cytokines in Diabetic Retinopathy. |
Young Jin Song, Jong Hyun Jung, Do Gyun Kim |
Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea. kimdk89@empas.com |
당뇨망막병증의 전방수내 사이토카인 분석 |
송영진⋅정종현⋅김도균 |
Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea |
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Abstract |
PURPOSE To investigate the relationship between the concentration of aqueous humor cytokines and the severity of diabetic retinopathy. METHODS: Thirty-six subjects were included in the control, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR) groups, each group has 12 patients. Aqueous levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha) were investigated according to the severity of diabetic retinopathy. RESULTS: When the control group was compared with the PDR and NPDR groups, aqueous levels of IL-6 were significantly higher in PDR patients than in those of both the control and NPDR groups (p = 0.016 and p = 0.003, respectively). The aqueous levels of VEGF were significantly higher in the eyes of PDR patients than in those of the control group (p = 0.003). There were no statistically significant differences between the 3 groups with regard to other cytokines. CONCLUSIONS: Aqueous levels of IL-6 and VEGF were higher in the eyes of PDR patients than in those of healthy controls. |
Key Words:
Aqueous humor;Cytokine;Diabetic retinopathy |
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