J Korean Ophthalmol Soc > Volume 56(2); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(2):291-295.
DOI: https://doi.org/10.3341/jkos.2015.56.2.291    Published online February 15, 2015.
A Case of Toxic Keratitis due to Chronic Use of Sodium Hyaluronate Eyedrops.
Eun Jung Lee, In Jeong Lyu, Joo Hyun, Dong Hui Lim, Tae Young Chung
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. tychung@skku.edu
히알우론산나트륨 점안액의 장기 사용으로 인한 독성 각막염 1예
이은정⋅유인정⋅현 주⋅임동희⋅정태영
성균관대학교 의과대학 삼성서울병원 안과학교실
To report a case of toxic keratitis due to chronic use of sodium hyaluronate eyedrops. CASE SUMMARY: A 74-year-old female visited our clinic with severe ocular pain and decreased vision in both eyes. She had received refractive surgeries in both eyes 10 years prior. She had been using sodium hyaluronate eyedrops for the treatment of dry eye symptoms for 10 years. Slit-lamp examination revealed inferior punctate erosions in the inferior part of the cornea in both eyes. With her history of chronic use of sodium hyaluronate and after ophthalmologic examination, we suspected keratitis medicamentosa due to sodium hyaluronate eyedrops. We discontinued the eyedrops she was using and prescribed autologous serum. One month later, ocular discomfort and decreased vision were improved and corneal erosions were decreased. CONCLUSIONS: In the present case, toxic keratitis was assumed to be associated with the use of sodium hyaluronate eyedrops and corneal erosions improved after the eyedrops were discontinued. We suggest sodium hyaluronate eyedrops are potentially hazardous and recommend a regular follow-up should be performed by a qualified ophthalmologist.
Key Words: Keratitis medicamentosa;Sodium hyaluronate;Toxic keratitis

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