J Korean Ophthalmol Soc > Volume 56(7); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(7):1044-1050.
DOI: https://doi.org/10.3341/jkos.2015.56.7.1044    Published online July 15, 2015.
Internal Limiting Membrane Peeling Using 0.025% Brilliant Blue G During Vitrectomy.
Beom Seok Choi, Min Kyu Shin, Sung Who Park, Ik Soo Byon, Ji Eun Lee, Boo Sup Oum
1Department of Ophthalmology, Pusan National University School of Medicine, Busan, Korea. jlee@pusan.ac.kr
2Medical Research Institute, Pusan National University Hospital, Busan, Korea.
3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
4Jung Gun Eye Hospital, Busan, Korea.
유리체절제술 중 0.025% Brilliant Blue G를 이용한 내경계막 제거
최범석1⋅신민규1,2⋅박성후1,2⋅변익수1,3⋅이지은1,2⋅엄부섭4
부산대학교 의학전문대학원 안과학교실1, 부산대학교병원 의학연구소2, 양산부산대학교병원 의생명융합연구소3, 정근안과병원4
Received: 27 September 2014   • Revised: 5 February 2015   • Accepted: 20 May 2015
Abstract
PURPOSE
To evaluate 0.025% brilliant blue G (BBG) for staining the internal limiting membrane (ILM) during vitrectomy. METHODS: In a retrospective, non-comparative clinical case series, we analyzed consecutive 111 patients who underwent pars plana vitrectomy and removal of the ILM after staining using BBG solution. BBG was dissolved and diluted with balanced salt solution at a concentration of 0.025% and then sterilized by filtering through a 0.22 microm millipore filter. The prepared BBG solution was injected into the vitreous cavity over the macula after removal of the vitreous and excessive solution was removed immediately. RESULTS: The ILM was successfully removed without use of additional adjuvant in all cases. Mean best corrected visual acuity (log MAR) was significantly improved from 0.80 +/- 0.44 at baseline to 0.40 +/- 0.39 at 6 months postoperatively (p < 0.001). One case each of endophthalmitis and diabetic papillopathy developed. The relationship when using BBG solution was not identified as complications were not observed in the other patients who underwent vitrectomy using the same BBG solution on the same day. One idiopathic epiretinal membrane patient had visual acuity loss more than 2 lines. During the follow-up period, other complications suspected to be associated with the use of BBG solution were not observed. CONCLUSIONS: A BBG solution (0.025%) was effective in staining the ILM for removal. Complications associated with the use of BBG solution were not observed.
Key Words: Brilliant blue G;Internal limiting membrane


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