J Korean Ophthalmol Soc > Volume 56(10); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(10):1610-1616.
DOI: https://doi.org/10.3341/jkos.2015.56.10.1610    Published online October 15, 2015.
Comparison of Patient Characteristics in Thyroid-Associated Ophthalmopathy with and without Strabismus.
Kyung Jun Choi, Seung Hyun Kim, Joo Yeon Lee
1Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. kimleejy@hallym.or.kr
2Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
사시가 동반된 갑상샘눈병증 환자군과 사시가 없는 갑상샘눈병증 환자군의 특징 비교
최경준1⋅김승현2⋅이주연1
한림대학교 의과대학 한림대학교성심병원 안과학교실1, 고려대학교 의과대학 안과학교실2
Received: 17 April 2015   • Revised: 1 June 2015   • Accepted: 23 July 2015
Abstract
PURPOSE
To determine immunochemical and clinical differences in thyroid-associated ophthalmopathy (TAO) patients with restrictive strabismus and without strabismus. METHODS: A retrospective chart review of 15 TAO patients with strabismus (25 eyes) and 24 TAO patients without strabismus (39 eyes) who presented to the Ophthalmology Clinic between August 2011 and December 2013 was performed. Visual acuity, intraocular pressure (IOP), Hertel exophthalmometry, soft tissue score, and enlargement of extraocular muscles on computed tomography (CT) were obtained and compared in each group. Thyroid related autoantibody (thyroid-stimulating hormone receptor antibody, TRAb; thyroid peroxidase antibody, TPOAb; anti-thyroglobulin antibody, TgAb) titers and positive rates were obtained at the time of diagnosis or before treatment and analyzed. RESULTS: The gender and smoking proportion were not significantly different between the 2 groups. The mean age of TAO patients with strabismus was 52.53 years and of TAO patients without strabismus 40.33 years (p = 0.004). The differences in visual acuity and IOP between the 2 groups were not significant. Hertel exophthalmometry showed less proptotis in the TAO with strabismus group than the TAO without strabismus group (16.84 mm versus 18.67 mm). The soft tissue score was not significantly different. The extraocular muscle enlargement rate of TAO with strabismus was significantly higher than in TAO without strabismus group. In the TAO with strabismus group, TRAb level was higher than in the TAO without strabismus group (p = 0.021). CONCLUSIONS: The TAO with strabismus group was older and had higher positive rate, level of TRAb, and extraocular muscle enlargement rate on CT than the TAO without strabismus group. Furthermore, proptosis was less definite in the TAO with strabismus group.
Key Words: Autoantibody;Extraocular muscle enlargement;Restrictive strabismus;Thyroid associated ophthalmopathy;Thyroid stimulating hormone receptor antibody


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