J Korean Ophthalmol Soc > Volume 54(1); 2013 > Article
Journal of the Korean Ophthalmological Society 2013;54(1):104-111.
DOI: https://doi.org/10.3341/jkos.2013.54.1.104    Published online January 15, 2013.
Comparison of Serum Homocysteine, Vitamin B12, Vitamin B6 and Folate Levels in Different Glaucoma Types.
Byung Ju Choo, Young Hoon Hwang, Joo Hwa Lee, Tai Jin Kim
1Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. lasiklove@hanmail.net
2Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University, Seoul, Korea.
3Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
녹내장 유형에 따른 혈청 호모시스테인, 비타민 B12, 비타민 B6 및 엽산 농도의 비교
주병주1⋅ 황영훈2⋅이주화3⋅김태진1
Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine1, Seoul, Korea
Department of Ophthalmology, Kim’s Eye Hospital, Myung-Gok Eye Research Institute, Konyang University2, Seoul, Korea
Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine3, Seoul, Korea
Abstract
PURPOSE
To compare the levels of serum homocysteine, vitamin B12, vitamin B6 and folate in patients with normal-tension glaucoma, pseudoexfoliation glaucoma and high-tension glaucoma. METHODS: Thirty-two healthy subjects, 35 patients with normal-tension glaucoma, 22 patients with pseudoexfoliation glaucoma and 31 patients with high-tension glaucoma were included in the present study. Fasting venous samples were collected from all the participants. The levels of serum homocysteine, vitamin B12, vitamin B6 and folate were measured. One-way analysis of variance was used for the comparison of homocysteine, vitamin B12, vitamin B6 and folate levels among the 4 groups. RESULTS: The mean homocysteine levels in the pseudoexfoliation glaucoma and high-tension glaucoma group were 17.91 +/- 5.11 and 17.60 +/- 3.89 micromol/l, respectively, which were significantly higher than that of the control group (p = 0.014, p = 0.013, respectively). The mean vitamin B6 levels in the pseudoexfoliation glaucoma and high-tension glaucoma group were 17.67 +/- 14.32 and 17.00 +/- 10.58 nmol/l, respectively, which were significantly lower than that of the control group (p = 0.026, p = 0.008, respectively). CONCLUSIONS: Hyperhomocysteinemia may play a role as a risk factor in the development or progression of pseudoexfoliation glaucoma and high-tension glaucoma.
Key Words: High-tension glaucoma;Homocysteine;Normal-tension glaucoma;Pseudoexfoliation glaucoma;Vitamin B6
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