| Inflammatory Cytokines in the Vitreous of Rabbits after Photocoagulation Using Pattern Scanning and Conventional Laser. |
|
Young Rock Choi, Ik Soo Byon, Seung Uk Lee, Min Kyu Shin, Ji Eun Lee, Boo Sup Oum |
1Daeyoun Saint Mary Eye Clinic, Busan, Korea.
2Department of Ophthalmology, Pusan National University School of Medicine, Busan, Korea. bsoum@pusan.ac.kr
3BiomMedical Instutute, Pusan National University Hospital, Busan, Korea.
4Department of Ophthalmology, Kosin University College of Medicine, Busan, Korea. |
| 패턴 스캐닝 레이저과 기존 방법을 이용한 광응고술 후 가토 유리체강의 염증성 사이토카인 |
|
최영락1⋅변익수2,3⋅이승욱4⋅신민규2⋅이지은2,3⋅엄부섭2,3 |
Daeyoun Saint Mary Eye Clinic1, Busan, Korea
Department of Ophthalmology, Pusan National University School of Medicine2, Busan, Korea
BiomMedical Instutute, Pusan National University Hospital3, Busan, Korea
Department of Ophthalmology, Kosin University College of Medicine4, Busan, Korea |
|
|
| Abstract |
PURPOSE
To compare concentration of cytokines in the vitreous of rabbit eyes after photocoagulation using a short-pulse pattern scanning laser (PASCAL) or a conventional laser. METHODS: Laser photocoagulation was performed using PASCAL (duration 0.02 seconds) in the right eyes and a conventional laser (duration 0.1 seconds) in the left eyes of 13 pigmented rabbits. To obtain ophthalmoscopically similar mild burns, power was adjusted during the photocoagulation. The rabbits were sacrificed at 1, 3 or 7 days after photocoagulation to investigate histological changes. Levels of interleukins (IL)-1beta, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha in the vitreous humors of ten rabbits were measured using enzyme-linked immunosorbent assay before treatment and at 1, 3 and 7 days after photocoagulation. RESULTS: Histological changes were comparable between the two groups. IL-1beta and TNF-alpha were not detectable. IL-6 did not change significantly. IL-8 increased at day 3 and day 7, but no significant difference was observed between the two groups (p>0.05). CONCLUSIONS: When ophthalmoscopically similar mild burn intensity was achieved, conventional and PASCAL treatments of rabbit eyes caused no difference in intravitreal concentration of inflammatory cytokines. |
| Key Words:
Cytokine;Interleukin;Patterned scanning laser;Photocoagulation |
|
PDF Links
Full text via DOI
Download Citation
