J Korean Ophthalmol Soc > Volume 54(7); 2013 > Article
Journal of the Korean Ophthalmological Society 2013;54(7):1013-1018.
DOI: https://doi.org/10.3341/jkos.2013.54.7.1013    Published online July 15, 2013.
Effects of Cyclosporine 0.05% Ophthalmic Emulsion to Improve Reduction of Tear Production after Cataract Surgery.
Ae Ri Yoo, Hyung Bin Hwang, Hyun Kyung Kim, Sung Kun Chung
1Department of Ophthalmology and Visual Science, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. eyedoc@catholic.ac.kr
2Department of Ophthalmology and Visual Science, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
싸이클로스포린 0.05% 점안액이 백내장 수술 후 발생하는 눈물분비 감소에 미치는 영향
유애리1⋅황형빈1⋅김현경2⋅정성근1
Department of Ophthalmology and Visual Science, St. Mary’s Hospital1, St. Vincent’s Hospital2, The Catholic University of Korea College of Medicine, Seoul, Korea
Abstract
PURPOSE
To evaluate the efficacy of cyclosporine 0.05% in reduced tear production sign and dry eye symptoms after cataract surgery. METHODS: This hospital-based prospective randomized trial included 43 patients of 83 eyes who underwent phacoemulsification. Tear break-up time, Schirmer's test, corneal and conjunctival stain, and ocular surface disease index were performed for all patients at preoperative 1 day, and 1 day, 1 week, 1 month, and 2 months postoperatively. Group 1 received carboxymethylcellulose 0.5%, group 2 received twice-daily cyclosporine 0.05%, and group 3 did not receive any additional eye drops. RESULTS: There was no statistically significant difference between the 3 groups in outcome measures. Two months after cataract surgery, the cyclosporine group showed improved tear break-up time, Schirmer's test I, and corneal and conjunctival staining. CONCLUSIONS: Cyclosporine 0.05% therapy reduced dry eye signs and symptoms after cataract surgery.
Key Words: Cataract surgery;Cyclosporine;Dry eye;Phacoemulsification


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