J Korean Ophthalmol Soc > Volume 54(8); 2013 > Article
Journal of the Korean Ophthalmological Society 2013;54(8):1255-1260.
DOI: https://doi.org/10.3341/jkos.2013.54.8.1255    Published online August 15, 2013.
The Efficacy of Vaccinium Uliginosum for Early Age-Related Macula Degeneration.
Hyun Kyung Kil, You Mi Song, Koi Chun
Department of Ophthalmology, Daejin Medical Hospital, Seongnam, Korea. hk9111@dmc.or.kr
초기 황반변성 환자에서 들쭉 추출물의 효과
Department of Ophthalmology, Daejin Medical Hospital, Seongnam, Korea
To evaluate the effect of Bog Bilberry (Vaccinium uliginosum) extract in eyes with early age-related macular degeneration (AMD). METHODS: Forty-four eyes of forty four patients with early AMD were included in this randomized, double-blinded, and placebo-controlled study. All participants were randomly assigned to either the placebo group (n = 24), or the bog bilberry extract group (n = 20). Before drug administration, an ophthalmic examination which included slit lamp microscopy, best corrected visual acuity, and intraocular pressure was performed, and repeated 1and 3 months after treatment. Objective scatter index, glare and tear film break-up time were checked by Optical Quality Analysis System (OQAS, Visiometrics, Spain) and drusen volume, central macular thickness, and RPE and IS/OS junction thickness were investigated with spectral-domain optical coherence tomography (Spectralis, Heidelberg, Germany). RESULTS: In the bog bilberry extract group, RPE and IS/OS junction thickness was significantly increased compared to the placebo group after 3 months of drug administration. CONCLUSIONS: Bog Bilberry extract may play a favorable role in preventing the atrophic change of RPE and IS/OS junction layer and the progression of early macular degeneration.
Key Words: Age-related macular degeneration;Bog bilberry;IS/OS junction;Optical coherence tomography

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