A Case of Neuromyelitis Optica with Paraneoplastic Syndrome in Hepatocellular Carcinoma.

Kil, Hyun Kyung; Lee, Gu Eun; Hong, Hyuk Jin; Park, Sang Jong; Sin, Sang Kun

doi:2013.54.10.1630

J Korean Ophthalmol Soc > Volume 54(10); 2013 > Article

Case Report

Journal of the Korean Ophthalmological Society 2013;54(10):1630-1634.
DOI: https://doi.org/10.3341/jkos.2013.54.10.1630 Published online October 15, 2013.

A Case of Neuromyelitis Optica with Paraneoplastic Syndrome in Hepatocellular Carcinoma.

Hyun Kyung Kil, Gu Eun Lee, Hyuk Jin Hong, Sang Jong Park, Sang Kun Sin

¹Department of Ophthalmology, DMC BunDang Je Sang Genera Hospital, Seongnam, Korea. hk9111@dmc.or.kr
²Department of Neurology, DMC BunDang Je Sang General Hospital, Seongnam, Korea.
³Department of Radiology, DMC BunDang Je Sang General Hospital, Seongnam, Korea.
⁴Department of Gastroenterology, DMC BunDang Je Sang General Hospital, Seongnam, Korea.
⁵SinSangKun Neurologic Clinic, Seongnam, Korea.

간암 환자에서 방종양성 증후군으로 발생한 시신경척수염 1예

길현경¹⋅이구은²⋅홍혁진³⋅박상종⁴⋅신상건⁵

Department of Ophthalmology, DMC BunDang Je Sang General Hospital¹, Seongnam, Korea
Department of Neurology, DMC BunDang Je Sang General Hospital², Seongnam, Korea
Department of Radiology, DMC BunDang Je Sang General Hospital³, Seongnam, Korea
Department of Gastroenterology, DMC BunDang Je Sang General Hospital⁴, Seongnam, Korea
SinSangKun Neurologic Clinic⁵, Seongnam, Korea

Abstract

PURPOSE
We report a case of neuromyelitis optica (Devic's syndrome) with hepatocellular carcinoma. CASE SUMMARY: A 70-year-old male with hepatocellular carcinoma presented with bilateral visual loss. A relative afferent pupillary defect was not observed in either eye due to bilateral mydriasis. On brain MRI, there was no specific finding, however, on spine MRI, multiple and severe myelopathies were observed. After high-dose methylprednisolone pulse therapy, the visual acuity was 0.03 in the right eye and counting fingers at 30 cm in the left eye. CONCLUSIONS: We encountered a case of neuromyelitis optica involving bilateral optic neuropathy in hepatocelluar carcinoma. Therefore, in patients with an optic neuropathy of uncertain etiology, clinicians should consider performing a systemic evaluation.

Key Words: Devic's syndrome;Hepatocellular carcinoma;Neuromyelitis optica;Optic neuritis