J Korean Ophthalmol Soc > Volume 52(4); 2011 > Article
Journal of the Korean Ophthalmological Society 2011;52(4):454-461.
DOI: https://doi.org/10.3341/jkos.2011.52.4.454    Published online April 15, 2011.
False Negative Findings of Optical Coherence Tomography in Eyes with Localized Nerve Fiber Layer Defects.
Sung Min Kang, Ki Bang Uhm
Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea. KBUhm@hanyang.ac.kr
국소적 망막신경섬유층결손안에서 빛간섭단층촬영의 가음성 결과와 관련된 요인
Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea
Correspondence:  Ki Bang Uhm, MD, PhD
To identify the risk factors associated with false negative findings of optical coherence tomography (Stratus OCT) in patients with photographic localized retinal nerve fiber layer (RNFL) defects. METHODS: Twenty-four patients with preperimetric glaucoma and 173 patients with perimetric glaucoma, all with localized RNFL defects were included in the present study. The patients were divided into 2 groups according to the presence or absence of detection of photographic defects by OCT. Gender, age, refractive error, diabetes, hypertension, central corneal thickness, type of glaucoma, mean deviation, pattern standard deviation, average RNFL thickness, disc area, and photographic RNFL defect related variables (location, number, and angular width) were compared between the 2 groups. Each variable was initially evaluated by univariate analysis and significant variables (p < 0.1) were included in the logistic regression analysis. RESULTS: Photographic RNFL defects were not detected by OCT in 51 (25.9%) of the 197 eyes. The angular locations and widths of RNFL defects by OCT were significantly correlated with those of RNFL defects by red-free RNFL photographs (Pearson correlation coefficient R = 0.98 and 0.64, respectively). Logistic regression analysis revealed the risk factors for false negative findings of OCT included average RNFL thickness (odds ratio = 1.106, 95% confidence interval [CI] = 1.057-1.156, p < 0.001) and angular width of defect (odds ratio = 0.929, 95% CI = 0.884-0.977, p = 0.004). CONCLUSIONS: This present study suggests that false negative findings of OCT in patients with photographic localized RNFL defects were associated with thicker RNFL thickness and smaller angular width of RNFL defect.
Key Words: Glaucoma;Optical coherence tomography;Retinal nerve fiber layer defect;Risk factor

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