J Korean Ophthalmol Soc > Volume 52(7); 2011 > Article
Journal of the Korean Ophthalmological Society 2011;52(7):825-831.
DOI: https://doi.org/10.3341/jkos.2011.52.7.825    Published online July 15, 2011.
Efficacy of Autologous Plasmin-Assisted Vitrectomy for Rhegmatogenous Retinal Detachment.
Chaerin Park, Sun Ho Lee, Jang Won Heo, Hum Chung
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. hjw68@snu.ac.kr
2Seoul Artificial Eye Center, Institutes for Biomedical Research, Seoul National University Hospital, Seoul, Korea.
3Department of Ophthalmology, College of Medicine, Jeju National University, Jeju, Korea.
열공망막박리에서 자가플라스민을 이용한 유리체절제술의 효과
박채린1,2⋅이선호3⋅허장원1,2⋅정 흠1,2
Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea Seoul Artificial Eye Center, Institutes for Biomedical Research, Seoul National University Hospital2, Seoul, Korea Department of Ophthalmology, College of Medicine, Jeju National University3, Jeju, Korea
Abstract
PURPOSE
To evaluate the efficacy and complication of autologous plasmin (AP) injected before vitrectomy for rhegmatogenous retinal detachment (RRD). METHODS: Intravitreal AP injection (0.2 ml) was performed on the eyes without posterior vitreous detachment (PVD) 20 minutes before the vitrectomy for RRD. The extent of PVD was evaluated intraoperatively. Surgical PVD induction was performed and the ease of the procedure was graded. The extent of PVD, ease of PVD induction, and complications (including incidence of iatrogenic retinal break) were compared to those of the control eyes. In order to evaluate complications and measure activated partial thromboplastin time, a microbial culture of injected AP was performed and the rate of postoperative intraocular hemorrhage was investigated. Change in visual acuity and the rate of retinal reattachment were compared in order to evaluate the long-term surgical outcome. RESULTS: The extent of PVD was greater in the AP group than in the control group, and vitreal separation was facilitated by intravitreal AP injection. However, ease of PVD induction and frequency of iatrogenic retinal break found were not significantly different between cases and controls. Neither postoperative intraocular hemorrhage nor systemic coagulation abnormality occurred. Postoperative endophthalmitis and positive microbial culture of the AP solution were also not reported. There was no significant difference in the change in visual acuity and the rate of retinal reattachment between the two groups. CONCLUSIONS: Intravitreal AP injection can facilitate vitrectomy for RRD and has no effect on the rate of retinal reattachment.
Key Words: Autologous plasmin;Rhegmatogenous retinal detachment;Vitrectomy


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