J Korean Ophthalmol Soc > Volume 52(8); 2011 > Article
Journal of the Korean Ophthalmological Society 2011;52(8):910-915.
DOI: https://doi.org/10.3341/jkos.2011.52.8.910    Published online August 15, 2011.
Botulinum Toxin A Treatment for Patients with Periorbital Spasm after Facial Nerve Paresis.
Jae Yeun Lee, Jong Seo Park, Helen Lew
Department of Ophthalmology, Bundang CHA Medical Center, CHA University, Seongnam, Korea. eye@cha.ac.kr
얼굴신경마비 후 얼굴연축 환자에서 보툴리눔 독소를 이용한 치료
Department of Ophthalmology, Bundang CHA Medical Center, CHA University, Seongnam, Korea
To evaluate clinical features of periorbital spasm and facial asymmetry in the patients who recovered poorly from Bell's palsy and facial trauma and to investigate the effect of Botulinum toxin A as a treatment for periorbital spasm and facial asymmetry. METHODS: Between November 2001 and January 2010, Botulinum toxin injection was performed in 17 patients who had blepharospasm and facial asymmetry following poor recovery from facial palsy. The past history, trauma history, clinical manifestation of blepharospasm, Botulinum toxin A injection dose, injection site, frequency of injection, and duration of effect was evaluated. Data was analyzed using the Mann-Whitney U test, SPSS 12.0. RESULTS: The mean number of injections was 2.7 +/- 2.4 times and the mean dose per injection unit was 12.2 +/- 1.2 units. The Botulinum toxin effect lasted 6.9 +/- 5.5 months in Bell's palsy patients, and 8.0 +/- 4.2 months in trauma patients. There was no significant difference between the 2 groups. Most patients reported improvement of periorbital spasm and facial asymmetry. After treatment, 1 patient complained of epiphora and 1 patient complained of ptosis; conservative treatment was performed for these patients. CONCLUSIONS: Blepharospasm can be treated and a cosmetic improvement in facial symmetry can be achieved by Botulinum toxin A injection in the patients who recover poorly from facial palsy.
Key Words: Aberrant facial nerve regeneration;Blepharospasm;Botulinum toxin;Facial palsy;Hypertonicity;Synkinesis

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