| Long-Term Results after Three or More Penetrating Keratoplasties and Risk Factors for Graft Failure. |
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Jae Yong Jang, Je Moon Woo, Kyung Chul Yoon |
1Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
2Department of Ophthalmology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. |
| 3회 이상 전층각막이식술을 시행 받은 환자의 장기간 임상결과와 이식실패의 위험인자 |
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장재용1⋅우제문2⋅윤경철1 |
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Department of Ophthalmology, Chonnam National University Medical School1, Gwangju, Korea Department of Ophthalmology, Ulsan University Hospital, University of Ulsan College of Medicine2, Ulsan, Korea |
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| Abstract |
PURPOSE
To evaluate the primary indications, surgical outcomes, causes and risk factors for graft failure in patients with three or more penetrating keratoplasty (PKP) surgeries. METHODS: We retrospectively analyzed indications for the initial corneal graft, survival periods, causes and risk factors for failure in 25 patients (26 eyes) who had undergone three or more PKP with minimum follow-up periods of nine months. RESULTS: The most common primary indications were herpes simplex keratitis (26.9%), followed by fungal keratitis (19.2%) and bacterial keratitis (11.5%). The average survival period of graft in three or more PKP was 12.9 +/- 9.1 months. As the frequency of PKP increased, the survival period became shorter; the survival period was the longest in pseudophakic bullous keratopathy and the shortest in herpes simplex keratitis. The most common cause of graft failure was allograft rejection (82.8%), and the risk factors for graft failure were short interval between penetrating keratoplasties and corneal neovascularization. CONCLUSIONS: In three or more PKP, as the frequency of PKP increases, the survival period becomes shorter. Short interval between keratoplasties and cornel neovascularization were risk factors for graft failure; this results must be considered before surgery. |
| Key Words:
Graft Failure;Risk Factor;Three or More Penetrating Keratoplasties |
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