The Effect of Dorzolamide-Timolol and Latanoprost on Redox Cycle in Aqueous Humor of Rabbit.

Park, Sang Woo; Lee, Seung Hyun; Mun, Gui Hyeong

doi:2009.50.3.424

J Korean Ophthalmol Soc > Volume 50(3); 2009 > Article

Original Article

Journal of the Korean Ophthalmological Society 2009;50(3):424-428.
DOI: https://doi.org/10.3341/jkos.2009.50.3.424 Published online March 15, 2009.

The Effect of Dorzolamide-Timolol and Latanoprost on Redox Cycle in Aqueous Humor of Rabbit.

Sang Woo Park, Seung Hyun Lee, Gui Hyeong Mun

Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea. exo70@naver.com

도졸라마이드-티몰롤과 라타노프로스트가 가토 방수의 산화환원계에 미치는 영향

박상우ㆍ이승현ㆍ문귀형

Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea

Abstract

PURPOSE
To evaluate the effect of dorzolamide-timolol and latanoprost on redox cycle of superoxide dismutase (SOD) and ascorbic acid in the aqueous humor of the rabbit. METHODS: Group 1 (20 eyes of 10 rabbits) was instilled with dorzolamide-timolol in the right eye and Group 2 (20 eyes of 10 rabbits) was instilled with latanoprost in the same manner. Four weeks after instillation, SOD activity and ascorbic acid concentration were analyzed. RESULTS: In Group 1, SOD activity and ascorbic acid concentration of the right eye and left eye were 15.7% and 19.3% (p=0.27), 2.7 pM and 2.6 pM (p=0.47), respectively. In Group 2, SOD activity and ascorbic acid concentration of the right and left eye were 22.3% and 27.6% (p=0.14), 2.3 pM and 2.1 pM (p=0.89), respectively. CONCLUSIONS: There was no significant difference of SOD activity and ascorbic acid concentration between both eyes in Group 1 and 2.

Key Words: Ascorbic acid;Dorzolamide-timolol;Latanoprost;Superoxide dismutase