Clinical Research on Effectiveness of Mitomycin C on Primary Pterygium With Limbal-Conjunctival Autograft.

Lee, Byeong Hee; Lee, Jong Wook; Park, Young Jeung; Lee, Kyoo Won

doi:2009.50.7.996

J Korean Ophthalmol Soc > Volume 50(7); 2009 > Article

Original Article

Journal of the Korean Ophthalmological Society 2009;50(7):996-1004.
DOI: https://doi.org/10.3341/jkos.2009.50.7.996 Published online July 1, 2009.

Clinical Research on Effectiveness of Mitomycin C on Primary Pterygium With Limbal-Conjunctival Autograft.

Byeong Hee Lee, Jong Wook Lee, Young Jeung Park, Kyoo Won Lee

Cheil Eye Hospital, Daegu, Korea. eyepark9@dreamwiz.com

자가윤부결막이식술을 시행한 원발군날개에서 마이토마이신 C의 효용성에 대한 임상연구

이병희ㆍ이종욱ㆍ박영정ㆍ이규원

Cheil Eye Hospital, Daegu, Korea

Abstract

PURPOSE
To evaluate the effectiveness of Mitomycin C used as a combined therapy along with limbal-conjunctival autograft for primary pterygium. METHODS: Thirty eyes of 29 patients received Mitomycin C (0.02% MMC 3 minutes) with limbal-conjunctival autograft, and 30 eyes of 28 patients received limbal-conjunctival autograft alone. Recurrence and complications were evaluated in the patients at 2 weeks, 1, 3, 6 and 12 months postoperatively. RESULTS: Mean follow-up periods were 13.4+/-2.1 and 13.9+/-2.9 months, respectively. Between the two groups, recurrence in the conjunctiva or the cornea was not observed during the follow-up period. In the Mitomycin C use group, complications included a granuloma at the donor site (1 eye, 3.3%), wound dehiscence (2 eyes, 6.7%), and subgraft hemorrhage (2 eyes, 6.7%). In comparison, in the group treated with limbal-conjunctival autograft alone, complications included granuloma at the donor site (1 eye, 3.3%), pseudopterygium at the donor site (1 eye, 3.3%), wound dehiscence (3 eyes, 10%), and subgraft hemorrhage (2 eyes, 6.7%). CONCLUSIONS: The use of Mitomycin C as an adjuvant therapy has no significant effect on the recurrence rate in primary pterygium with limbal-conjunctival autograft.

Key Words: Limbal-conjunctival autograft;Mitomycin C;Pterygium