J Korean Ophthalmol Soc > Volume 50(7); 2009 > Article
Journal of the Korean Ophthalmological Society 2009;50(7):1027-1034.
DOI: https://doi.org/10.3341/jkos.2009.50.7.1027    Published online July 15, 2009.
Short-term Efficacy of Intravitreal Ranibizumab for Myopic Choroidal Neovascularization.
Min Hye Song, Joon Yong Kim, Young Jung Roh
Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea. youngjungroh@hanmail.net
근시성 맥락막 신생혈관에서 유리체강내 라니비주맙 주입술의 단기효과
송민혜ㆍ김준용ㆍ노영정
Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract
PURPOSE
To evaluate the effects of intravitreal ranibizumab in myopic choroidal neovascularization (CNV). METHODS: Patients who underwent intravitreal ranibizumab injection for myopic CNV, and were followed up more than 6 months, and their records were retrospectively investigated. The best corrected visual acuity, central macular thickness, and leak in fluorescein angiography were compared at baseline, and at 1, 3, and 6 months after injection. RESULTS: Twenty-one eyes of 18 patients were evaluated. The mean best corrected visual acuity (logMAR) was 1.23+/-0.65, 0.96+/- 0.40, 0.95+/-0.67, and 0.83+/-0.58 at baseline, 1, 3, and 6 months, respectively (p<0.001, p=0.006, p=0.001). The mean central macular thickness was 233.42+/-65.55 microm, 204.14+/-65.29 micrometer, and 157.76+/-71.45 microm at baseline, 3, and 6 months, respectively (p<0.001). In fluorescein angiography at 6 months after injection, regression was observed in 12 eyes, and fibrosis in 9 eyes. CONCLUSIONS: Intravitreal ranibizumab injection for myopic CNV in Korean patients appeared to be effective, resulting in regression of lesion and improvement of visual acuity.
Key Words: Choroidal neovascularization;Pathologic myopia;Ranibizumab (Lucentis(R))


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