Photopic Negative Response (PhNR) in Normal Subjects.

Kim, Hoon Dong; Park, Sang Hyouk; Park, Su Eun; Ohn, Young Hoon

doi:2009.50.10.1531

J Korean Ophthalmol Soc > Volume 50(10); 2009 > Article

Original Article

Journal of the Korean Ophthalmological Society 2009;50(10):1531-1538.
DOI: https://doi.org/10.3341/jkos.2009.50.10.1531 Published online October 15, 2009.

Photopic Negative Response (PhNR) in Normal Subjects.

Hoon Dong Kim, Sang Hyouk Park, Su Eun Park, Young Hoon Ohn

¹Department of Ophthalmology, College of Medicine, Soonchunhyang University, Bucheon, Korea. yhohn@schbc.ac.kr
²Department of Ophthalmology, College of Medicine, Soonchunhyang University, Gumi, Korea.
³Department of Ophthalmology, Gangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

정상안에서의 명음성반응

김훈동¹ㆍ박상혁²ㆍ박수은³ㆍ온영훈¹

Department of Ophthalmology, College of Medicine, Soonchunhyang University¹, Bucheon, Korea / Department of Ophthalmology, College of Medicine, Soonchunhyang University², Gumi, Korea / Department of Ophthalmology, Gangnam Sacred Heart Hospital, College of Medicine, Hallym University³, Seoul, Korea

Abstract

PURPOSE
To evaluate the nature of photopic negative response (PhNR) in normal subjects. METHODS: The electroretinogram (ERG) waves were recorded in 52 eyes of 26 normal subjects with UTAS E-3000(R) (LKC Technologies Inc., Gaithersberg, MD, USA). Photopic cone response was obtained for analysis from a white flash with white background illumination (group 1) and a red flash with blue background illumination (group 2), after stimulations ranging from 0.007674 cd.s/m2 (-25dB) to 7.736 cd.s/m2 (5dB) with a 5dB interval. RESULTS: PhNRs were observed in all 52 eyes in group 1 stimulated with the white flash at 0.9933 cd.s/m2 (-4dB). PhNRs were also observed in all 52 eyes in group 2 at 2.4297 cd.s/m2 (0dB) after stimulation with the red flash. There was correlation between the amplitudes of PhNR and intensity of stimuli (p<0.001). Implicit times of PhNR were correlated with age in both groups, but amplitudes decreased with age in group 1. CONCLUSIONS: The amplitudes of PhNR were correlated with intensity of stimuli and age had an influence on PhNR. Standardization of examination conditions is necessary when recording PhNR.

Key Words: Electroretinogram;Photopic negative response;Stimulus