J Korean Ophthalmol Soc > Volume 51(2); 2010 > Article
Journal of the Korean Ophthalmological Society 2010;51(2):175-179.
DOI: https://doi.org/10.3341/jkos.2010.51.2.175    Published online February 15, 2010.
Effect of Hormone Replacement Therapy on Dry Eye Syndrome in Postmenopausal Women: A Prospective Study.
Jung Hyun Moon, Jee Woong Jung, Kyung Hwan Shin, Hye Jung Paik
1Department of Ophthalmology, Gachon University Gil Medical Center, Incheon, Korea. hjpaik@gilhospital.com
2Department of Ophthalmology, The Armed Forces Hampyeong Hospital, Hampyeong, Korea.
폐경기 여성의 호르몬 대치요법이 안구건조증상에 미치는 영향: 전향적 연구보고
문정현1ㆍ정지웅2ㆍ신경환1ㆍ백혜정1
Department of Ophthalmology, Gachon University Gil Medical Center1, Incheon, Korea Department of Ophthalmology, The Armed Forces Hampyeong Hospital2, Hampyeong, Korea
Abstract
PURPOSE
To evaluate the effects of conjugated hormone replacement therapy (HRT) on dry eye syndrome in postmenopausal women. METHODS: Thirty-six healthy postmenopausal women (72 eyes) were included in this three-month prospective study. Schirmer test, tear film break-up time (BUT), fluorescein staining score and symptom score were performed on all patients at the time of enrollment, one month and three months after initiation of HRT. All patients received HRT consisting of conjugated estrogen and progesterone taken orally in a continuous combined regimen. RESULTS: Symptom score significantly decreased from 2.10+/-0.79 before HRT to 1.32+/-0.84 after one month and to 0.88+/-0.67 after three months (p<0.001). In addition, tear film BUT measurements significantly increased from 6.04+/-2.54 seconds to 7.99+/-2.43 seconds after one month and to 8.93+/-2.20 after three months (p<0.001). The fluorescein staining score was 0.94+/-0.71 before HRT and decreased to 0.42+/-0.60 after one month and to 0.22+/-0.42 after three months (p<0.001). CONCLUSIONS: Hormone replacement therapy consisting of conjugated estrogen and progesterone significantly improved the symptoms and signs of dry eye syndrome in postmenopausal women.
Key Words: Dry eye syndrome;Hormone replacement therapy;Postmenopausal woman


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