| Cinical Manifestations and Prognosis of Cytomegalovirus Retinitis. |
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Young Kyo Kwun, Ju Byung Chae, Don Il Ham |
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. oculus@naver.com
2Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea. |
| 거대세포바이러스 망막염의 임상양상 및 예후에 대한 고찰 |
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권영교1ㆍ채주병2ㆍ함돈일1 |
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Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine1, Seoul, Korea Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center2, Seoul, Korea |
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| Abstract |
PURPOSE
Cytomegalovirus (CMV) retinitis is common in patients with immunodeficient conditions caused by acquired immunodeficiency syndrome (AIDS), cytotoxic chemotherapy and immunosuppresive treatment. The purpose of this study was to assess the clinical manifestations and prognosis of CMV retinitis cases. METHODS: Thirty-one eyes of 21 patients who were diagnosed with CMV retinitis were retrospectively reviewed. The clinical manifestations and prognosis of all patients were analyzed. RESULTS: The average age of patients was 24.4+/-19.8 years. Eight patients were female and 13 patients were male. The predisposing conditions of patients were leukemia (nine patients), immunosuppressed conditions due to organ transplantation (three patients), AIDS (two patients) and other (seven patients). Eleven patients exhibited bilateral disease. The mean follow-up period was 31.3 months, and there were no differences between mean initial visual acuity (0.70+/-0.31) and mean visual acuity (0.77+/-0.20) at final visit. The major causes of visual loss were retinitis and atrophic changes involving the macula. Although retinitis was successfully treated with anti-viral agents in all cases, cataract (10 eyes, 31.3%), cystoid macular edema (four eyes, 12.5%), retinal detachment (two eyes, 6.3%), epiretinal membrane (two eyes, 6.3%) and immune recovery uveitis (two eyes, 6.3%) developed after the initial treatment. CONCLUSIONS: Although the visual prognosis of CMV retinitis was relatively good after administration of appropriate antiviral therapy, clinicians should remain alert for the development of late complications, including retinal detachment, cystoid macular edema and immune recovery uveitis. |
| Key Words:
Cinical manifestations;Cytomegalovirus retinitis;Prognosis |
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